时反声学与超声辅助递药增强脑内药物传递。
Time-reversal acoustics and ultrasound-assisted convection-enhanced drug delivery to the brain.
机构信息
School of Chemical and Biomolecular Engineering and Department of Biomedical Engineering, Olin Hall, Cornell University, Ithaca, New York 14853, USA.
出版信息
J Acoust Soc Am. 2013 Aug;134(2):1569-75. doi: 10.1121/1.4812879.
Abstract
Time-reversal acoustics is an effective way of focusing ultrasound deep inside heterogeneous media such as biological tissues. Convection-enhanced delivery is a method of delivering drugs into the brain by infusing them directly into the brain interstitium. These two technologies are combined in a focusing system that uses a "smart needle" to simultaneously infuse fluid into the brain and provide the necessary feedback for focusing ultrasound using time-reversal acoustics. The effects of time-reversal acoustics-focused ultrasound on the spatial distribution of infused low- and high-molecular weight tracer molecules are examined in live, anesthetized rats. Results show that exposing the rat brain to focused ultrasound significantly increases the penetration of infused compounds into the brain. The addition of stabilized microbubbles enhances the effect of ultrasound exposure.
摘要
声时反转技术是一种将超声波聚焦于生物组织等不均匀介质深处的有效方法。对流增强递送是一种通过将药物直接注入脑间质来向大脑递送药物的方法。这两种技术结合在一个聚焦系统中，该系统使用“智能针”将流体同时注入大脑，并使用声时反转技术提供聚焦超声波所需的反馈。本文在活体麻醉大鼠中研究了声时反转聚焦超声对注入的低和高分子量示踪分子的空间分布的影响。结果表明，使大鼠大脑暴露于聚焦超声下可显著增加注入化合物向大脑的穿透。添加稳定化微泡可增强超声暴露的效果。
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