1 Institute of Psychological Sciences, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom.
J Int Neuropsychol Soc. 2013 Oct;19(9):971-6. doi: 10.1017/S1355617713000830. Epub 2013 Aug 8.
Intraindividual variability (IIV) refers to reaction time (RT) variation across the trials of a given cognitive task. Little research has contrasted different measures of IIV or assessed how many RT trials are required to provide a robust measure of the construct. We, therefore, investigated three measures of IIV (raw SD, coefficient of variation, and intraindividual SD statistically removing time-on-task effects) in relation to frontal white matter hyperintensities (obtained through structural MRI) in 415 cognitively normal community-dwelling adults aged 44 to 48 years. Results indicated the three IIV measures did not differ greatly in predictions of white matter hyperintensities, although it is possible that time-on-task effects were influential. As few as 20 trials taking approximately 52 s to administer provided a reliable prediction of frontal white matter hyperintensities. We conclude that future work should evaluate the comparative utility of different IIV measures in relation to persons exhibiting clear neuropathology.
个体内变异性 (IIV) 是指在给定认知任务的试验中反应时间 (RT) 的变化。很少有研究对比不同的 IIV 测量方法，也没有评估需要多少个 RT 试验才能提供对该结构的稳健测量。因此，我们在 415 名认知正常的社区居住成年人（年龄在 44 至 48 岁之间）中，通过结构磁共振成像 (MRI) 获得的额白质高信号，研究了三种 IIV 测量方法（原始 SD、变异系数和统计上消除任务时间影响的个体内 SD）与额白质高信号之间的关系。结果表明，三种 IIV 测量方法在预测白质高信号方面差异不大，尽管任务时间的影响可能是有影响的。只需要进行大约 52 秒的 20 次试验，就可以可靠地预测额白质高信号。我们的结论是，未来的工作应该评估不同的 IIV 测量方法在与表现出明显神经病理学的人有关的情况下的比较效用。
