Division of Neuroradiology, Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Neuroimaging Clin N Am. 2013 Aug;23(3):393-406. doi: 10.1016/j.nic.2012.10.004. Epub 2013 Feb 27.
Neurodegenerative dementias are characterized by elevated myoinositol and decreased N-acetylaspartate (NAA) levels. The increase in myoinositol seems to precede decreasing NAA levels in Alzheimer's diseases. NAA/myo-inositol ratio in the posterior cingulate gyri decreases with increasing burden of Alzheimer's disease pathologic conditions. Proton magnetic resonance spectroscopy ((1)H MRS) is sensitive to the pathophysiologic processes associated with the risk of dementia in patients with mild cognitive impairment. Although significant progress has been made in improving the acquisition and analysis techniques in (1)H MRS, translation of these technical developments to clinical practice have not been effective because of the lack of standardization for multisite applications and normative data and an insufficient understanding of the pathologic basis of (1)H MRS metabolite changes.
神经退行性痴呆的特征是肌醇水平升高和 N-乙酰天冬氨酸（NAA）水平降低。肌醇的增加似乎先于阿尔茨海默病中 NAA 水平的降低。在后扣带回皮层，阿尔茨海默病病理状态的负担增加，NAA/肌醇比值降低。质子磁共振波谱（1H MRS）对与轻度认知障碍患者痴呆风险相关的病理生理过程敏感。尽管在提高 1H MRS 的采集和分析技术方面取得了重大进展，但由于缺乏多站点应用和规范数据的标准化以及对 1H MRS 代谢物变化病理基础的理解不足，这些技术发展尚未有效地转化为临床实践。
