[维吾尔族患者霍奇金淋巴瘤中EB病毒感染及潜伏膜蛋白2A的表达]

[Epstein-Barr virus infection and expression of latent membrane protein 2A in Hodgkin's lymphoma of Uygur patients].

作者信息

Li Xun, Yang Shun-e, Guo Yun-quan, Zang Su-hong, Guo Li, Gulikezi Wushouer, Zhao Bing, Liu Wei, Bai Jing-ping

机构信息

Department of Medical Oncology, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi 830011, China.

出版信息

Zhonghua Bing Li Xue Za Zhi. 2013 Apr;42(4):239-42. doi: 10.3760/cma.j.issn.0529-5807.2013.04.006.

DOI:10.3760/cma.j.issn.0529-5807.2013.04.006

PMID:23928530

Abstract

OBJECTIVE

To investigate Epstein-Barr virus(EBV) infection in Hodgkin's lymphoma (HL) of Uygur patients and related clinicopathological characteristics.

METHODS

EBV-encoded small RNA (EBER) was detected in 40 cases of HL and 20 cases of lymphoid reactive hyperplasia by in-situ hybridization. Expression of LMP2A in HL was investigated by immunohistochemistry.

RESULTS

EBV was detected in 26/40 (65.0%) of HL and 5/20 of lymphoid reactive hyperplasia (P < 0.05). The expression level of EBER showed significant difference among various histological subtypes of HL (P < 0.05) and between patients with and without B symptom (P = 0.02). However, no difference was found in relation to gender, clinical stage and tumor burden. The expression of LMP2A in the mixed cellularity and nodular sclerosis classical HL associated with EBV infection was 57.7% (15/26). Expression of LMP2A was not detected in lymphoid reactive hyperplasia cases.

CONCLUSION

Uyghur patients with Hodgkin's lymphoma have a high infection rate of EBV and distinct clinicopathologic characteristics.

摘要

目的

探讨维吾尔族患者霍奇金淋巴瘤（HL）中EB病毒（EBV）感染情况及相关临床病理特征。

方法

采用原位杂交法检测40例HL患者及20例淋巴组织反应性增生患者的EBV编码小RNA（EBER）。采用免疫组织化学法研究HL中LMP2A的表达情况。

结果

HL患者中26/40（65.0%）检测到EBV，淋巴组织反应性增生患者中5/20检测到EBV（P<0.05）。HL各组织学亚型间EBER表达水平差异有统计学意义（P<0.05），有B症状与无B症状患者间差异有统计学意义（P = 0.02）。但在性别、临床分期及肿瘤负荷方面未发现差异。与EBV感染相关的混合细胞型和结节硬化型经典HL中LMP2A表达率为57.7%（15/26）。淋巴组织反应性增生病例中未检测到LMP2A表达。