Department of Chemistry, IIT Bombay, Powai, Mumbai-400076, India.
Chem Commun (Camb). 2013 Sep 28;49(75):8362-4. doi: 10.1039/c3cc44562c.
Selective hydrogenolysis of C-CN bonds can allow chemists to take advantage of ortho-directing ability, α-C-H acidity and electron withdrawing ability of the cyano group for synthetic manipulations. We have discovered hydrogenolysis of aryl and aliphatic cyanides under just 1 bar of hydrogen by using a nickel catalyst. This protocol was applied in the aryl cyanide directed functionalization reaction and α-substitution of benzyl cyanides.
C-CN 键的选择性氢解可以使化学家利用氰基的邻位导向能力、α-C-H 酸性和吸电子能力进行合成操作。我们已经发现，通过使用镍催化剂，在仅仅 1 巴氢气的压力下就可以实现芳基和脂肪族腈的氢解。该方案已应用于芳基氰化物导向的官能团化反应和苄基氰化物的 α-取代反应。
