Kitada Munehiro, Koya Daisuke
Diabetology & Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa, Japan.
Methods Mol Biol. 2013;1048:95-107. doi: 10.1007/978-1-62703-556-9_8.
Calorie restriction (CR) has a variety of effects on extending lifespan and delaying the onset of age-related diseases, and it is accepted as the only established experimental antiaging intervention. Several pharmacological agents that can replicate the beneficial effects of CR, called calorie restriction mimetics (CRMs), have been identified. The nutrient-sensing pathways including those involving sirtuins (especially SIRT1) and mammalian target of rapamycin (mTOR) may regulate the physiology of CR, and candidate CRMs that modulate these specific pathways have been identified and investigated using animal models. In this chapter, we focus on candidate CRMs including sirtuin-activating compounds (STACs) and mTOR inhibitors, their slowing of aging, and methods for evaluation of lifespan and metabolic disorders.
热量限制（CR）对延长寿命和延缓与年龄相关疾病的发生具有多种作用，并且它被公认为唯一已确立的实验性抗衰老干预措施。已鉴定出几种能够复制CR有益作用的药物制剂，称为热量限制模拟物（CRM）。包括那些涉及沉默调节蛋白（特别是SIRT1）和雷帕霉素靶蛋白（mTOR）的营养感应途径可能调节CR的生理学，并且已经使用动物模型鉴定和研究了调节这些特定途径的候选CRM。在本章中，我们重点关注包括沉默调节蛋白激活化合物（STAC）和mTOR抑制剂在内的候选CRM、它们延缓衰老的作用以及寿命和代谢紊乱的评估方法。
