Mullerworth M H, Daniel F J, Lie J T
J Thorac Cardiovasc Surg. 1975 Jul;70(1):89-99.
Experimental angiographic, histologic, and ultrastructural observations were obtained from dogs to determine the fate of internal mammary artery (IMA) implants and aorta-coronary bypass (ACB) conduits in the 3 month postoperative period. Angiographic implant patency and evidence of implants forming collaterals with the coronary circulation did not accurately reflect anatomic luminal narrowing. Subendothelial fibrocellular proliferation similar to that described in saphenous vein grafts occurred with regularity in all IMA implants and ACB conduits. The intimal changes were much more severe in the IMA implants as compared to the ACB conduits: There was 25 to 95 per cent liminal narrowing in the IMA implants, whereas the ACB conduits rarely showed greater than 25 per cent luminal narrowing. Both reduced flow and surgical trauma appeared to be influential determining factors of the intimal proliferative process, whereas devascularization alone seemed less important.
通过对犬进行实验性血管造影、组织学和超微结构观察，以确定乳内动脉（IMA）植入物和主动脉 - 冠状动脉旁路（ACB）血管在术后3个月的转归。血管造影显示植入物的通畅情况以及植入物与冠状动脉循环形成侧支的证据，并不能准确反映管腔的解剖学狭窄。所有IMA植入物和ACB血管均规律性地出现了类似于大隐静脉移植物中所描述的内皮下纤维细胞增殖。与ACB血管相比，IMA植入物中的内膜变化更为严重：IMA植入物中管腔狭窄为25%至95%，而ACB血管很少显示管腔狭窄超过25%。血流减少和手术创伤似乎都是内膜增生过程的重要决定因素，而单纯的血管离断似乎不太重要。
