Isabelle Carrière, PhD, Inserm U1061 and University of Montpellier I, Montpellier, France; Joanne Ryan, PhD, Inserm U1061 and University of Montpellier I, Montpellier, France, and Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia; Joanna Norton, PhD, Jacqueline Scali, MSc, Inserm U1061 and University of Montpellier I, Montpellier, France; Robert Stewart, PhD, Institute of Psychiatry, King's College London, UK; Karen Ritchie, PhD, Inserm U1061 and University of Montpellier I, Montpellier, France, and Faculty of Medicine, Imperial College, St Mary's Hospital, London, UK; Marie Laure Ancelin, PhD, Inserm U1061 and University of Montpellier I, Montpellier, France.
Br J Psychiatry. 2013 Sep;203(3):303-9. doi: 10.1192/bjp.bp.112.124685. Epub 2013 Aug 8.
There are conflicting data on the role of anxiety in predicting mortality.
To evaluate the 10-year mortality risk associated with anxiety in community-dwelling elderly people.
Using data from 718 men and 1046 women aged 65 years and over, gender-stratified associations of anxiety symptoms (Spielberger State-Trait Anxiety Inventory, third tertile) and current DSM-IV anxiety disorder including generalised anxiety disorder (GAD) and phobia with all-cause and cardiovascular mortality were determined.
In women, mortality risk was increased for anxiety disorder and GAD in multivariate Cox models (hazard ratio (HR) = 1.53, 95% CI 1.02-2.27 and HR = 2.04, 95% CI 1.08-3.86 respectively), whereas for phobia it was nearly significant (HR = 1.52, 95% CI 0.94-2.47). Anxiety trait symptoms became non-significant as a result of the confounding effect of depressive symptoms. Anxiety disorder was associated with cardiovascular mortality in univariate analysis (HR = 2.42, 95% CI 1.16-5.07). No significant associations were found in men.
Our study suggests a gender-specific association of anxiety and mortality.
焦虑在预测死亡率方面的作用存在相互矛盾的数据。
评估社区居住的老年人中焦虑症状与 10 年死亡率风险的相关性。
使用来自 718 名男性和 1046 名 65 岁及以上的女性的数据，对焦虑症状（斯皮尔伯格状态-特质焦虑量表，第三三分位数）和当前 DSM-IV 焦虑障碍（包括广泛性焦虑障碍（GAD）和恐惧症）与全因和心血管死亡率的性别分层相关性进行了评估。
在女性中，焦虑障碍和 GAD 在多变量 Cox 模型中的死亡风险增加（危险比（HR）=1.53，95%置信区间（CI）1.02-2.27 和 HR = 2.04，95% CI 1.08-3.86），而恐惧症则接近显著（HR = 1.52，95% CI 0.94-2.47）。由于抑郁症状的混杂效应，焦虑特质症状变得不显著。在单变量分析中，焦虑障碍与心血管死亡率相关（HR = 2.42，95% CI 1.16-5.07）。在男性中未发现显著相关性。
我们的研究表明焦虑与死亡率之间存在性别特异性关联。
