Université de Bejaia, Faculté des Sciences de la Nature et de la vie, Laboratoire de Biochimie Appliquée, Bejaia, 06000, Algérie.
J Sci Food Agric. 2014 Mar 30;94(5):951-4. doi: 10.1002/jsfa.6341. Epub 2013 Sep 4.
Viticultural residues from commercial viticultural activities represent a potentially important source of bioactive stilbenes such as resveratrol. The main aim of the present study was therefore to isolate, identify and perform biological assays against amyloid-β peptide aggregation of original stilbenes from Vitis vinifera shoots.
A new resveratrol oligomer, (Z)-cis-miyabenol C (3), was isolated from Vitis vinifera grapevine shoots together with two newly reported oligostilbenes from Vitis vinifera shoots, vitisinol C (1) and (E)-cis-miyabenol C (2), and six known compounds: piceatannol, resveratrol, (E)-ε-viniferin (trans-ε-viniferin), ω-viniferin, vitisinol C and (E)-miyabenol C. The structures of these resveratrol derivatives were established on the basis of detailed spectroscopic analysis including nuclear magnetic resonance experiments. All the newly reported compounds were tested for their anti-aggregative activity against amyloid-β fibril formation. Vitisinol C was found to exert a significant activity against amyloid-β aggregation.
Vitis vinifera grapevine shoots are potentially interesting as a source of new bioactive stilbenes, such as vitisinol C.
商业葡萄栽培活动产生的葡萄栽培残留物是白藜芦醇等生物活性芪类物质的潜在重要来源。因此，本研究的主要目的是从葡萄藤芽中分离、鉴定并对原芪类物质进行抗淀粉样β肽聚集的生物测定。
从 Vitis vinifera 葡萄藤芽中分离出一种新的白藜芦醇低聚物（Z）-顺式-米雅本醇 C（3），以及两种新报道的 Vitis vinifera 芽中的低聚芪类物质，即白藜芦醇（1）和（E）-顺式-米雅本醇 C（2），以及六种已知化合物：白皮杉醇、白藜芦醇、（E）-ε-viniferin（反式-ε-viniferin）、ω-viniferin、vitisinol C 和（E）-miyabenol C。这些白藜芦醇衍生物的结构是基于详细的光谱分析，包括核磁共振实验来确定的。所有新报道的化合物均进行了抗淀粉样β纤维形成的抗聚集活性测试。发现白藜芦醇具有显著的抗淀粉样β聚集活性。
Vitis vinifera 葡萄藤芽是具有潜在应用价值的新型生物活性芪类物质的来源，如 vitisinol C。
