具有可调双光子作用截面的 GFP 生色团刚性类似物的独特家族，可用于生物成像。
A unique family of rigid analogues of the GFP chromophore with tunable two-photon action cross-sections for biological imaging.
机构信息
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan 410082 (China).
出版信息
Angew Chem Int Ed Engl. 2013 Sep 16;52(38):10018-22. doi: 10.1002/anie.201303179. Epub 2013 Aug 8.
PMID:23929806
Abstract
Conformationally restricted analogues of the GFP chromophore have been synthesized. The spectroscopic properties of GCTPOC, a unique family with tunable two-photon action cross-sections, were investigated. GCTPOC could be used as a robust two-photon platform for development of a two-photon fluorescent thiol sensor, which could stain endogenous thiols both in vitro and in vivo.
摘要
已合成 GFP 生色团的构象限制类似物。研究了具有可调双光子作用截面的独特家族 GCTPOC 的光谱性质。GCTPOC 可用作坚固的双光子平台，开发双光子荧光硫醇传感器，该传感器可在体外和体内对内源性硫醇进行染色。
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