Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD, USA; Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2013 Nov-Dec;5(6):646-61. doi: 10.1002/wnan.1239. Epub 2013 Aug 8.
¹⁹F is the second most sensitive stable nucleus for magnetic resonance imaging (MRI). Because there is no endogenous ¹⁹F signal, ¹⁹F MRI is much more suited for quantification and tracking than ¹H MRI. However, ¹⁹F MRI is not in clinical use because in spite of more than three decades of research, there are no approved ¹⁹F imaging agents. New approaches and new methodologies are needed to move the field forward. Water-soluble fluorinated dendrimers present a promising alternative to conventional perfluorocarbon emulsions. This article outlines recent development of fluorinated dendrimers as ¹⁹F imaging agents. This is not meant to be a comprehensive review of ¹⁹F imaging agents, for which there is an excellent recent review by Knight et al. Rather, the article aims to give an insider's account on research efforts in this exciting and challenging field.
¹⁹F 是用于磁共振成像（MRI）的第二灵敏稳定的原子核。由于没有内源性的 ¹⁹F 信号，¹⁹F MRI 比 ¹H MRI 更适合定量和追踪。然而，¹⁹F MRI 并未在临床上使用，因为尽管经过了三十多年的研究，仍没有获得批准的 ¹⁹F 成像剂。需要新的方法和方法来推动该领域的发展。水溶性氟化树状大分子是传统全氟碳乳液的有前途的替代品。本文概述了氟化树状大分子作为 ¹⁹F 成像剂的最新进展。这并不是对 Knight 等人最近对 ¹⁹F 成像剂进行的全面综述，而是旨在提供该令人兴奋和具有挑战性的领域的研究工作的内部人士观点。
