Kühn Simone, Vanderhasselt Marie-Anne, De Raedt Rudi, Gallinat Jürgen
Max Planck Institute for Human Development, Center for Lifespan Psychology, Lentzeallee 94, 14195 Berlin, Germany, Ghent University, Department of Experimental Clinical and Health Psychology, 9000 Gent, Belgium, and Charité University Medicine, St Hedwig Krankenhaus, Clinic for Psychiatry and Psychotherapy, 10115 Berlin, Germany Max Planck Institute for Human Development, Center for Lifespan Psychology, Lentzeallee 94, 14195 Berlin, Germany, Ghent University, Department of Experimental Clinical and Health Psychology, 9000 Gent, Belgium, and Charité University Medicine, St Hedwig Krankenhaus, Clinic for Psychiatry and Psychotherapy, 10115 Berlin, Germany Max Planck Institute for Human Development, Center for Lifespan Psychology, Lentzeallee 94, 14195 Berlin, Germany, Ghent University, Department of Experimental Clinical and Health Psychology, 9000 Gent, Belgium, and Charité University Medicine, St Hedwig Krankenhaus, Clinic for Psychiatry and Psychotherapy, 10115 Berlin, Germany
Max Planck Institute for Human Development, Center for Lifespan Psychology, Lentzeallee 94, 14195 Berlin, Germany, Ghent University, Department of Experimental Clinical and Health Psychology, 9000 Gent, Belgium, and Charité University Medicine, St Hedwig Krankenhaus, Clinic for Psychiatry and Psychotherapy, 10115 Berlin, Germany.
Soc Cogn Affect Neurosci. 2014 Sep;9(9):1320-4. doi: 10.1093/scan/nst117. Epub 2013 Aug 7.
Human beings are constantly engaged in thought. Sometimes thoughts occur repetitively and can become distressing. Up to now the neural bases of these intrusive or unwanted thoughts is largely unexplored. To study the neural correlates of unwanted thoughts, we acquired resting-state fMRI data of 41 female healthy subjects and assessed the self-reported amount of unwanted thoughts during measurement. We analyzed local connectivity by means of regional homogeneity (ReHo) and functional connectivity of a seed region. More unwanted thoughts (state) were associated with lower ReHo in right dorsolateral prefrontal cortex (DLPFC) and higher ReHo in left striatum (putamen). Additional seed-based analysis revealed higher functional connectivity of the left striatum with left inferior frontal gyrus (IFG) in participants reporting more unwanted thoughts. The state-dependent higher connectivty in left striatum was positively correlated with rumination assessed with a dedicated questionnaire focussing on trait aspects. Unwanted thoughts are associated with activity in the fronto-striatal brain circuitry. The reduction of local connectivity in DLPFC could reflect deficiencies in thought suppression processes, whereas the hightened activity in left striatum could imply an imbalance of gating mechanisms housed in basal ganglia. Its functional connectivity to left IFG is discussed as the result of thought-related speech processes.
人类一直在思考。有时，想法会反复出现并令人苦恼。到目前为止，这些侵入性或不必要想法的神经基础在很大程度上尚未得到探索。为了研究不必要想法的神经关联，我们获取了41名健康女性受试者的静息态功能磁共振成像（fMRI）数据，并在测量过程中评估了自我报告的不必要想法的数量。我们通过区域一致性（ReHo）和种子区域的功能连接性来分析局部连接性。更多的不必要想法（状态）与右侧背外侧前额叶皮质（DLPFC）中较低的ReHo以及左侧纹状体（壳核）中较高的ReHo相关。额外的基于种子的分析显示，在报告有更多不必要想法的参与者中，左侧纹状体与左侧额下回（IFG）之间的功能连接性更高。左侧纹状体中与状态相关的更高连接性与用一份专注于特质方面的专用问卷评估的反刍呈正相关。不必要想法与额-纹状体脑回路的活动有关。DLPFC中局部连接性的降低可能反映了思维抑制过程中的缺陷，而左侧纹状体中活动的增强可能意味着基底神经节中门控机制的失衡。其与左侧IFG的功能连接性被讨论为与思维相关的言语过程的结果。
