婆罗米酥油与吡拉西坦治疗失忆症的研究。
Study of Brāhmī Ghṛta and piracetam in amnesia.
作者信息
Yadav Kapil Deo, Reddy K R C, Kumar Vikas
机构信息
Department of Rasa Shastra, Faculty of Āyurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
出版信息
Anc Sci Life. 2012 Jul;32(1):11-5. doi: 10.4103/0257-7941.113791.
OBJECTIVE
To compare the effect of Brāhmī Ghṛta with piracetam (a reference standard chemical) in amnesia.
MATERIALS AND METHODS
Brāhmī Ghṛta contained Brāhmī (Bacopa monneri), Vacā (Acorus calamus), Kuṣṭha (Sassurea lappa), Śaṅkhapuṣpī (Convolvulos pluricalis), and Purāṇa Ghṛta, prepared as per snehapāka process. Antiamnesic activity of Brāhmī Ghṛta (400 and 800 mg/kg, p.o.) was evaluated in scopolamine (1 mg/kg, s.c.) induced amnesia in Charles Foster rats using elevated plus maze, passive avoidance, and active avoidance tests. Piracetam (500 mg/kg, p.o.) was used as standard drug. This effect was compared with standard chemical used in experimental study.
RESULTS
Brāhmī Ghṛta - (in both doses) and piracetam-treated rats significantly reversed the effect of scopolamine in modified elevated plus maze, passive avoidance, and active avoidance tests. But there were no significant differences observed in antiamnesic activity of Brāhmī Ghṛta and standard drug.
CONCLUSION
Brāhmī Ghṛta and piracetam produced significant beneficial effect on scopolamine-induced amnesic effect, but no significant difference was observed in between them.
目的
比较婆罗米酥油（Brāhmī Ghṛta）与吡拉西坦（一种参考标准化学药物）治疗失忆症的效果。
材料与方法
婆罗米酥油含有婆罗米（假马齿苋）、菖蒲（白菖蒲）、木香（云木香）、旋花（打碗花）和古方酥油，按照油煮法制备。采用高架十字迷宫、被动回避和主动回避试验，评估婆罗米酥油（400和800毫克/千克，口服）对东莨菪碱（1毫克/千克，皮下注射）诱导的查尔斯·福斯特大鼠失忆症的抗失忆活性。吡拉西坦（500毫克/千克，口服）用作标准药物。将此效果与实验研究中使用的标准化学药物进行比较。
结果
婆罗米酥油（两种剂量）和吡拉西坦治疗的大鼠在改良高架十字迷宫、被动回避和主动回避试验中显著逆转了东莨菪碱的作用。但婆罗米酥油和标准药物的抗失忆活性未观察到显著差异。
结论
婆罗米酥油和吡拉西坦对东莨菪碱诱导的失忆效应产生了显著有益作用，但两者之间未观察到显著差异。
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