Department of Social Medicine, School of Medicine, University of Crete, Heraklion, Greece.
Paediatr Perinat Epidemiol. 2013 Sep;27(5):461-71. doi: 10.1111/ppe.12074. Epub 2013 Jul 22.
Leptin is an adipocyte-secreted hormone that regulates energy homeostasis, while its role in fetal programming remains poorly understood. We aimed to evaluate the effect of maternal weight status on cord blood leptin levels and their combined effect on fetal growth.
We included 638 mother-child pairs from the prospective mother-child cohort 'Rhea' study in Crete, Greece with singleton pregnancies, providing cord blood serum samples for leptin analysis and complete data on birth outcomes. Multivariable logistic and linear regression models were used adjusting for confounders. Generalised additive models were used to explore the form of the relationship between cord leptin and continuous birth outcomes.
Log cord leptin was positively associated with birthweight {β-coef: 176.5 [95% confidence interval (CI): 133.0, 220.0] }, ponderal index (β-coef: 1.0 [95% CI: 0.6, 1.4] ) and gestational age (β-coef: 0.7 [95% CI: 0.5, 0.8] ). Excessive weight gain during pregnancy was associated with a threefold increased risk for cord hyperleptinaemia {relative risk (RR): 3.0, [95% CI: 1.5, 6.3] }. Maternal pre-pregnancy overweight/obesity [body mass index (BMI) ≥25 kg/m(2) ] increased the risk of giving birth to a hyperleptinaemic neonate (RR: 2.1 [95% CI: 1.4, 3.2] and the effect of log leptin on birthweight (β-coef: 219.1 [95% CI: 152.3, 285.9] compared with women with a BMI <25 kg/m(2) (β-coef: 150.5 [95% CI: 93.1, 207.9].
Higher cord blood leptin levels are associated with increased size at birth and gestational age, while maternal pre-pregnancy BMI and weight gain during pregnancy represent significant indicators of cord blood leptin.
瘦素是一种脂肪细胞分泌的激素，可调节能量稳态，但其在胎儿编程中的作用仍知之甚少。我们旨在评估母体体重状况对脐血瘦素水平的影响及其对胎儿生长的综合影响。
我们纳入了来自希腊克里特岛前瞻性母婴队列“Rhea”研究的 638 对母婴对，这些母婴对均为单胎妊娠，提供了用于瘦素分析的脐血血清样本，并提供了完整的出生结局数据。使用多变量逻辑和线性回归模型，调整混杂因素。使用广义加性模型探索脐血瘦素与连续出生结局之间关系的形式。
脐血瘦素与出生体重呈正相关{β-系数：176.5 [95%置信区间（CI）：133.0，220.0] }，体重指数（β-系数：1.0 [95% CI：0.6, 1.4] )和胎龄（β-系数：0.7 [95% CI：0.5, 0.8] )。怀孕期间体重过度增加与脐血高瘦素血症的三倍风险相关{相对风险（RR）：3.0，[95% CI：1.5, 6.3] }。母亲孕前超重/肥胖[体重指数（BMI）≥25 kg/m(2) ]增加了分娩高瘦素血症新生儿的风险（RR：2.1 [95% CI：1.4, 3.2]和瘦素对出生体重的影响（β-系数：219.1 [95% CI：152.3, 285.9]与 BMI<25 kg/m(2) 的女性相比（β-系数：150.5 [95% CI：93.1, 207.9]。
脐血瘦素水平升高与出生时的体型和胎龄增加有关，而母亲孕前 BMI 和怀孕期间体重增加是脐血瘦素的重要指标。
