Center of Excellence in Biotechnology Research .
Pharm Dev Technol. 2014 Sep;19(6):702-7. doi: 10.3109/10837450.2013.823992. Epub 2013 Aug 12.
Temperature-dependent solubility data of glibenclamide (GBN) in various ethanol-water mixtures is not reported in literature so far. Therefore, the aim of this study was to determine the mole fraction solubility of GBN in various ethanol-water mixtures at the temperature range of 293.15 to 318.15 K. The solubility of GBN was determined by reported shake flask method and the experimental data was fitted in thermodynamics-based modified Apelblat model. The solubility of GBN was found to be increased with increase in temperature and mass fraction of ethanol in ethanol-water mixtures. The experimental data of GBN was well correlated with the modified Apelblat model at each temperature range with correlation coefficient of 0.9940-1.0000. The relative absolute deviation (AD) was found to be less than 0.1% except in pure ethanol and water. The positive values of enthalpies and entropies for GBN dissolution indicated that its dissolution is endothermic and an entropy-driven process.
迄今为止，文献中尚未报道格列本脲（GBN）在各种乙醇-水混合物中的温度依赖性溶解度数据。因此，本研究的目的是在 293.15 至 318.15 K 的温度范围内确定 GBN 在各种乙醇-水混合物中的摩尔分数溶解度。GBN 的溶解度通过已报道的摇瓶法确定，并将实验数据拟合到基于热力学的修正 Apelblat 模型中。发现 GBN 的溶解度随温度升高和乙醇在乙醇-水混合物中的质量分数增加而增加。GBN 的实验数据在每个温度范围内均与修正 Apelblat 模型很好地相关，相关系数为 0.9940-1.0000。除了在纯乙醇和水中外，相对绝对偏差（AD）发现小于 0.1%。GBN 溶解的焓和熵的正值表明其溶解是吸热的，并且是熵驱动的过程。
