Schutte Nienke M, Hansell Narelle K, de Geus Eco J C, Martin Nicholas G, Wright Margaret J, Smit Dirk J A
Biological Psychology, Faculty of Psychology and Education, VU University Amsterdam, Amsterdam, The Netherlands.
Twin Res Hum Genet. 2013 Oct;16(5):962-9. doi: 10.1017/thg.2013.55. Epub 2013 Aug 9.
We examined the genetic architecture of functional brain connectivity measures in resting state electroencephalographic (EEG) recordings. Previous studies in Dutch twins have suggested that genetic factors are a main source of variance in functional brain connectivity derived from EEG recordings. In addition, qualitative descriptors of the brain network derived from graph analysis - network clustering and average path length - are also heritable traits. Here we replicated previous findings for connectivity, quantified by the synchronization likelihood, and the graph theoretical parameters cluster coefficient and path length in an Australian sample of 16-year-old twins (879) and their siblings (93). Modeling of monozygotic and dizygotic twins and sibling resemblance indicated heritability estimates of the synchronization likelihood (27-74%) and cluster coefficient and path length in the alpha and theta band (40-44% and 23-40% respectively) and path length in the beta band frequency (41%). This corroborates synchronization likelihood and its graph theoretical derivatives cluster coefficient and path length as potential endophenotypes for behavioral traits and neurological disorders.
我们研究了静息态脑电图（EEG）记录中功能性脑连接测量的遗传结构。之前对荷兰双胞胎的研究表明，遗传因素是EEG记录中功能性脑连接变异的主要来源。此外，通过图分析得出的脑网络定性描述符——网络聚类和平均路径长度——也是可遗传的性状。在此，我们在一个由16岁双胞胎（879对）及其兄弟姐妹（93名）组成的澳大利亚样本中，重复了之前关于连接性的研究结果，连接性通过同步似然性进行量化，并对图论参数聚类系数和路径长度进行了研究。对同卵双胞胎和异卵双胞胎以及兄弟姐妹相似性的建模表明，同步似然性（27 - 74%）以及α和θ频段的聚类系数和路径长度（分别为40 - 44%和23 - 40%）以及β频段频率的路径长度（41%）的遗传度估计值。这证实了同步似然性及其图论衍生指标聚类系数和路径长度作为行为特征和神经疾病潜在内表型的可能性。
