Schaake Wouter, de Groot Martijn, Krijnen Wim P, Langendijk Johannes A, van den Bergh Alfons C M
Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, The Netherlands; Hanze University of Applied Sciences, Professorship in Health Care and Nursing, Groningen, The Netherlands.
Radiother Oncol. 2013 Aug;108(2):299-305. doi: 10.1016/j.radonc.2013.06.039. Epub 2013 Aug 8.
To investigate the course of quality of life (QoL) among prostate cancer patients treated with external beam radiotherapy and to compare the results with QoL of a normal age-matched reference population.
The study population was composed of 227 prostate cancer patients, treated with radiotherapy. The EORTC QLQ-C30 was used to assess QoL before radiotherapy and six months, one year, two years and three years after completion of radiotherapy. Mixed model analyses were used to investigate longitudinal changes in QoL. QoL of prostate cancer patients was compared to that of a normative cohort using a multivariate analysis of covariance.
A significant decline in QoL was observed after radiotherapy (p<0.001). The addition of hormonal therapy to radiotherapy was associated with a lower level of role functioning. Patients with coronary heart disease and or chronic obstructive pulmonary disease or asthma had a significantly worse course in QoL. Although statistically significant, all differences were classified as small or trivial.
Prostate cancer patients experience a small worsening of QoL as compared with baseline and as compared with a normal reference population. As co-morbidity modulates patients' post-treatment QoL, a proper assessment of co-morbidity should be included in future longitudinal analyses on QoL.
研究接受外照射放疗的前列腺癌患者的生活质量（QoL）变化过程，并将结果与年龄匹配的正常参照人群的生活质量进行比较。
研究人群由227例接受放疗的前列腺癌患者组成。使用欧洲癌症研究与治疗组织生活质量核心问卷（EORTC QLQ-C30）在放疗前以及放疗结束后6个月、1年、2年和3年评估生活质量。采用混合模型分析来研究生活质量的纵向变化。使用多变量协方差分析将前列腺癌患者的生活质量与一个正常队列的生活质量进行比较。
放疗后观察到生活质量显著下降（p<0.001）。放疗联合激素治疗与角色功能水平较低有关。患有冠心病和/或慢性阻塞性肺疾病或哮喘的患者生活质量变化过程明显更差。尽管具有统计学意义，但所有差异均被归类为小或微不足道。
与基线相比以及与正常参照人群相比，前列腺癌患者的生活质量略有恶化。由于合并症会调节患者治疗后的生活质量，未来关于生活质量的纵向分析应纳入对合并症的适当评估。
