Voronina T A, Nerobkova L N, Kutepova O A, Gugutcidse D A
Institute of Pharmacology, Academy of Medical Sciences, USSR, Moscow.
Ann Ist Super Sanita. 1990;26(1):55-9.
The effects of 2-ethyl-6-methyl-3-hydroxypyridine (3-HP) on age-related and alcohol-induced impairment of memory and learning were studied in rats and mice. 3-HP was found to accelerate the acquisition of the conditioned reflex of active avoidance and to improve the retention of the conditioned reflex of passive avoidance in old (24 months) rats. 3-HP consumption during chronic (5 months) alcoholisation improved learning ability and prevented lipofuscin accumulation in brain of ethanol-treated mice. Extrapyramidal disorders after systemic administration of MPTP and intranigral injection of MPP+ depended on age of animals, dose of MPTP and MPP+, and duration of administration. The beneficial effects of 3-HP on age-related impairment of memory and learning and experimental parkinsonian syndrome may be due to its ability to inhibit the peroxidation of membrane lipids and increase cell resistance to different disturbing actions.
研究了2-乙基-6-甲基-3-羟基吡啶（3-HP）对大鼠和小鼠与年龄相关及酒精诱导的记忆和学习障碍的影响。发现3-HP可加速老年（24个月）大鼠主动回避条件反射的获得，并改善被动回避条件反射的保持。在慢性（5个月）酒精化期间摄入3-HP可提高乙醇处理小鼠的学习能力，并防止其大脑中脂褐素的积累。全身给予MPTP和黑质内注射MPP + 后出现的锥体外系障碍取决于动物年龄、MPTP和MPP + 的剂量以及给药持续时间。3-HP对与年龄相关的记忆和学习障碍及实验性帕金森综合征的有益作用可能归因于其抑制膜脂质过氧化和增加细胞对不同干扰作用抵抗力的能力。
