肿瘤细胞外酸度激活的纳米颗粒作为药物传递系统，增强癌症治疗。
Tumor extracellular acidity-activated nanoparticles as drug delivery systems for enhanced cancer therapy.
机构信息
Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, PR China.
Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, PR China.
出版信息
Biotechnol Adv. 2014 Jul-Aug;32(4):789-803. doi: 10.1016/j.biotechadv.2013.08.002. Epub 2013 Aug 7.
pH-responsive nanoparticles (NPs) are currently under intense development as drug delivery systems for cancer therapy. Among various pH-responsiveness, NPs that are designed to target slightly acidic extracellular pH environment (pHe) of solid tumors provide a new paradigm of tumor targeted drug delivery. Compared to conventional specific surface targeting approaches, the pHe-targeting strategy is considered to be more general due to the common occurrence of acidic microenvironment in solid tumors. This review mainly focuses on the design and applications of pHe-activated NPs, with special emphasis on pHe-activated surface charge reversal NPs, for drug and siRNA delivery to tumors. The novel development of NPs described here offers great potential for achieving better therapeutic effects in cancer treatment.
pH 响应型纳米粒子（NPs）作为癌症治疗的药物递送系统正在得到深入研究。在各种 pH 响应性中，设计用于靶向实体瘤稍酸性细胞外 pH 环境（pHe）的 NPs 为肿瘤靶向药物递送提供了新的范例。与传统的特异性表面靶向方法相比，由于实体瘤中酸性微环境的普遍存在，pHe 靶向策略被认为更为普遍。本综述主要关注 pH 激活型 NPs 的设计和应用，特别强调 pH 激活表面电荷反转 NPs，用于向肿瘤递送药物和 siRNA。这里描述的 NPs 的新进展为在癌症治疗中实现更好的治疗效果提供了巨大潜力。
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