Matsumoto S, Yoshimoto A, Ohsaki A, Murashima N, Ishii Y, Seno N
Dept. of Lung Surgery, Hiroshima City Hospital.
Gan To Kagaku Ryoho. 1990 Sep;17(9):1933-6.
A 61-year-old male patient who developed brain metastasis 6 months after the lung resection for adenocarcinoma was treated with the 3 courses of EAP (Etoposide 150 mg/body/course, ADR 40 mg/body/course, CDDP 100 mg/body/course). Although our doses were lesser than Preusser's, symptoms soon subsided, and brain CT revealed a complete disappearance of metastases 16 days after the beginning of the first EAP course. During 5 months of CR, the patient had enjoyed his common daily life, the relapse, however, occurred. Since brain metastasis is life threatening, such an effective regimen like EAP should be made further studies to it.
一名61岁男性患者,在肺腺癌切除术后6个月发生脑转移,接受了3个疗程的EAP方案治疗(依托泊苷150mg/体/疗程,多柔比星40mg/体/疗程,顺铂100mg/体/疗程)。尽管我们的剂量低于Preusser的剂量,但症状很快缓解,脑部CT显示在第一个EAP疗程开始后16天转移灶完全消失。在完全缓解的5个月期间,患者能够正常生活,但随后复发。由于脑转移危及生命,像EAP这样有效的治疗方案应进一步研究。