Benkelfat C, Nordahl T E, Semple W E, King A C, Murphy D L, Cohen R M
Section on Clinical Neuropharmacology, National Institute of Mental Health, Bethesda, Md.
Arch Gen Psychiatry. 1990 Sep;47(9):840-8. doi: 10.1001/archpsyc.1990.01810210048007.
In a recent study, we reported abnormal local cerebral glucose metabolic rates in the orbital frontal cortex of patients with obsessive-compulsive disorder. Eight patients with obsessive-compulsive disorder scanned previously were scanned again during treatment with the tricyclic antidepressant clomipramine hydrochloride. Comparisons of local cerebral glucose metabolic rates for both groups showed a relative decrease in regions of the orbital frontal cortex and the left caudate, and an increase in other areas of the basal ganglia, including the right anterior putamen. When comparing patients who responded well to clomipramine with those who were either poor or partial responders, we found significant decreases only in the left caudate of patients who responded well to the drug. The present study suggests that clomipramine-induced improvement in obsessive-compulsive symptoms is associated with a return of regional brain metabolism to a more normal level in regions of the orbital frontal cortex and the caudate nucleus.
在最近的一项研究中，我们报告了强迫症患者眶额皮质局部脑葡萄糖代谢率异常。之前接受过扫描的8名强迫症患者在使用三环类抗抑郁药盐酸氯米帕明治疗期间再次接受扫描。两组局部脑葡萄糖代谢率的比较显示，眶额皮质区域和左侧尾状核相对降低，基底神经节的其他区域包括右侧前壳核则升高。当比较对氯米帕明反应良好的患者与反应不佳或部分反应的患者时，我们发现仅在对该药反应良好的患者的左侧尾状核中有显著降低。本研究表明，氯米帕明诱导的强迫症症状改善与眶额皮质和尾状核区域的脑代谢恢复到更正常水平有关。
