Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
Eur J Heart Fail. 2014 Jan;16(1):15-24. doi: 10.1093/eurjhf/hft132. Epub 2013 Dec 3.
We aimed to perform a systematic review and meta-analysis to assess the association between serum uric acid and incident heart failure (HF)/prognosis of HF patients.
A systematic electronic literature search was conducted in Embase (Ovid SP, from 1974 to May 2013), Medline (Ovid SP, from 1946 to May 2013), and the Chinese Biomedical Literature Database (CBM, from 1978 to May 2013) to identify studies reporting on the association between serum uric acid and HF. Either a random effects model or a fixed effects model was used for pooling data. Five studies reporting on incident HF and 28 studies reporting on the adverse outcomes of HF patients were included. The results showed that hyperuricaemia was associated with an increased risk of incident HF [hazard ratio (HR) 1.65, 95% confidence interval (CI) 1.41-1.94], and the risk of all-cause mortality (HR 2.15, 95% CI 1.64-2.83), cardiovascular mortality (HR 1.45, 95% CI 1.18-1.78), and the composite of death or cardiac events (HR 1.39, 95% CI 1.18-1.63) in HF patients. For every 1 mg/dL increase in serum uric acid, the odds of development of HF increased by 19% (HR 1.19, 95% CI 1.17-1.21), and the risk of all-cause mortality and the composite endpoint in HF patients increased by 4% (HR 1.04, 95% CI 1.02-1.06) and 28% (HR 1.28, 95% CI 0.97-1.70), respectively. Subgroup analyses supported the positive association between serum uric acid and HF.
Elevated serum uric acid is associated with an increased risk of incident HF and adverse outcomes in HF patients.
本研究旨在进行系统评价和荟萃分析，以评估血清尿酸与心力衰竭（HF）事件（incident heart failure，HF）/HF 患者预后之间的相关性。
系统检索 Embase（Ovid SP，1974 年至 2013 年 5 月）、Medline（Ovid SP，1946 年至 2013 年 5 月）和中国生物医学文献数据库（CBM，1978 年至 2013 年 5 月）以识别报告血清尿酸与 HF 之间相关性的研究。采用随机效应模型或固定效应模型进行数据合并。纳入 5 项 HF 事件发生率研究和 28 项 HF 患者不良结局研究。结果显示，高尿酸血症与 HF 事件风险增加相关（危险比[HR] 1.65，95%置信区间[CI] 1.41-1.94），且全因死亡率（HR 2.15，95%CI 1.64-2.83）、心血管死亡率（HR 1.45，95%CI 1.18-1.78）和死亡或心脏事件复合终点（HR 1.39，95%CI 1.18-1.63）的风险也升高。血清尿酸每增加 1mg/dL，HF 发生的可能性增加 19%（HR 1.19，95%CI 1.17-1.21），HF 患者的全因死亡率和复合终点风险分别增加 4%（HR 1.04，95%CI 1.02-1.06）和 28%（HR 1.28，95%CI 0.97-1.70）。亚组分析支持血清尿酸与 HF 之间存在正相关关系。
血清尿酸水平升高与 HF 事件风险增加和 HF 患者不良结局相关。
