Postgraduate Program in Pharmacology, Department of Clinical and Toxicology Analysis, Center of Healthy Sciences, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil.
Inflammation. 2013 Dec;36(6):1539-47. doi: 10.1007/s10753-013-9697-9.
Metabolic syndrome (MetS) leads to changes in enzymatic activities, oxidative and inflammatory parameters. Adenosine deaminase (ADA), dipeptidyl peptidase IV (DPP-IV), butyrylcholinesterase (BuChE) and γ-glutamyltransferase (γ-GT) activities, C-reactive protein (hsCRP) and nitric oxide levels (NOx), as well as oxidative stress markers were analyzed in 39 subjects with MetS and 48 controls. Also, the influence of body mass index (BMI) and anthropometric measurements were evaluated. Disturbances in antioxidant defenses and higher γ-GT and BuChE activities, NOx and hsCRP levels were observed in subjects with MetS. These findings remained associated with MetS after adjustment for BMI, except for hsCRP. ADA was correlated with age, insulin levels and HOMA-IR index in MetS. DPP-IV and total cholesterol (TC), BuChE activity and TC, and VIT C and hsCRP levels also were correlated. The analyzed parameters may reflect the inflammatory state of the MetS, and could contribute to prevention and control of various aspects of this syndrome.
代谢综合征（MetS）导致酶活性、氧化和炎症参数发生变化。在 39 名 MetS 患者和 48 名对照者中分析了腺苷脱氨酶（ADA）、二肽基肽酶 IV（DPP-IV）、丁酰胆碱酯酶（BuChE）和γ-谷氨酰转移酶（γ-GT）活性、C 反应蛋白（hsCRP）和一氧化氮水平（NOx）以及氧化应激标志物。还评估了体重指数（BMI）和人体测量学测量的影响。在 MetS 患者中观察到抗氧化防御的破坏以及更高的 γ-GT 和 BuChE 活性、NOx 和 hsCRP 水平。这些发现与 MetS 相关，即使在调整 BMI 后也是如此，hsCRP 除外。ADA 与 MetS 中的年龄、胰岛素水平和 HOMA-IR 指数相关。DPP-IV 和总胆固醇（TC）、BuChE 活性和 TC 以及 VIT C 和 hsCRP 水平也相关。分析的参数可能反映了 MetS 的炎症状态，并有助于预防和控制该综合征的各个方面。
