Department of Psychiatry and Penn Center for Women's Behavioral Wellness, Perelman School of Medicine of the University of Pennsylvania, Pennsylvania, USA,
Arch Womens Ment Health. 2013 Dec;16(6):475-82. doi: 10.1007/s00737-013-0371-x. Epub 2013 Aug 10.
In this study, we evaluated the association between prenatal depression symptoms adverse birth outcomes in African-American women. We conducted a retrospective cohort study of 261 pregnant African-American women who were screened with the Edinburgh Postnatal Depression Scale (EPDS) at their initial prenatal visit. Medical records were reviewed to assess pregnancy and neonatal outcomes, specifically preeclampsia, preterm birth, intrauterine growth retardation, and low birth weight. Using multivariable logistic regression models, an EPDS score ≥10 was associated with increased risk for preeclampsia, preterm birth, and low birth weight. An EPDS score ≥10 was associated with increased risk for intrauterine growth retardation, but after controlling for behavioral risk factors, this association was no longer significant. Patients who screen positive for depression symptoms during pregnancy are at increased risk for multiple adverse birth outcomes. In a positive, patient-rated depression screening at the initial obstetrics visit, depression is associated with increased risk for multiple adverse birth outcomes. Given the retrospective study design and small sample size, these findings should be confirmed in a prospective cohort study.
在这项研究中，我们评估了产前抑郁症状与非裔美国女性不良出生结局之间的关联。我们对 261 名接受爱丁堡产后抑郁量表 (EPDS) 筛查的初诊产前就诊的非裔美国孕妇进行了回顾性队列研究。回顾了病历以评估妊娠和新生儿结局，特别是子痫前期、早产、宫内生长受限和低出生体重。使用多变量逻辑回归模型，EPDS 评分≥10 与子痫前期、早产和低出生体重的风险增加相关。EPDS 评分≥10 与宫内生长受限的风险增加相关，但在控制行为危险因素后，这种关联不再显著。在怀孕期间筛查出抑郁症状的患者有多种不良出生结局的风险增加。在初诊产科就诊时进行阳性、患者自评的抑郁筛查时，抑郁与多种不良出生结局的风险增加相关。鉴于回顾性研究设计和样本量小，这些发现应在前瞻性队列研究中得到证实。
