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CD52 as both a marker and an effector molecule of T cells with regulatory action: Identification of novel regulatory T cells.CD52作为具有调节作用的T细胞的标志物和效应分子：新型调节性T细胞的鉴定。
Cell Mol Immunol. 2013 Nov;10(6):456-8. doi: 10.1038/cmi.2013.38. Epub 2013 Sep 16.
2
Regulation unmasked by activation.激活揭示的调节
Nat Immunol. 2013 Jul;14(7):696-7. doi: 10.1038/ni.2646.
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T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10.可溶性 CD52 通过与抑制性受体 Siglec-10 的相互作用介导 T 细胞调节。
Nat Immunol. 2013 Jul;14(7):741-8. doi: 10.1038/ni.2610. Epub 2013 May 19.
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Immune regulation by CD52-expressing CD4 T cells.CD4 T 细胞表达 CD52 的免疫调节作用。
Cell Mol Immunol. 2013 Sep;10(5):379-82. doi: 10.1038/cmi.2013.35. Epub 2013 Aug 12.
5
CD52 is a novel costimulatory molecule for induction of CD4+ regulatory T cells.CD52是一种用于诱导CD4+调节性T细胞的新型共刺激分子。
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Depletion of CD52-positive cells inhibits the development of central nervous system autoimmune disease, but deletes an immune-tolerance promoting CD8 T-cell population. Implications for secondary autoimmunity of alemtuzumab in multiple sclerosis.CD52阳性细胞的耗竭抑制中枢神经系统自身免疫性疾病的发展，但会删除一个促进免疫耐受的CD8 T细胞群体。这对阿仑单抗在多发性硬化症中的继发性自身免疫的影响。
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Long-term immune reconstitution after anti-CD52-treated or anti-CD34-treated hematopoietic stem cell transplantation for severe T-lymphocyte immunodeficiency.针对严重T淋巴细胞免疫缺陷，经抗CD52治疗或抗CD34治疗的造血干细胞移植后的长期免疫重建。
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Alteration of CD39+Foxp3+ CD4 T cell and cytokine levels in EAE/MS following anti-CD52 treatment.抗CD52治疗后实验性自身免疫性脑脊髓炎/多发性硬化症中CD39+Foxp3+ CD4 T细胞及细胞因子水平的改变
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Different levels of CD52 antigen expression evaluated by quantitative fluorescence cytometry are detected on B-lymphocytes, CD 34+ cells and tumor cells of patients with chronic B-cell lymphoproliferative diseases.通过定量荧光细胞术评估，在慢性B细胞淋巴细胞增殖性疾病患者的B淋巴细胞、CD 34+细胞和肿瘤细胞上检测到不同水平的CD52抗原表达。
Cytometry B Clin Cytom. 2007 Sep;72(5):363-70. doi: 10.1002/cyto.b.20181.

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Single cell characterization of blood and expanded regulatory T cells in autoimmune polyendocrine syndrome type 1.1型自身免疫性多内分泌综合征中血液和扩增调节性T细胞的单细胞特征分析
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Single-cell RNA sequencing reveals peripheral blood mononuclear immune cell landscape associated with operational tolerance in a kidney transplant recipient.单细胞 RNA 测序揭示与肾移植受者免疫功能耐受相关的外周血单个核免疫细胞特征。
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Dysregulation of T-B-T lymphocyte cooperation is associated with unfavorable anti-PD-1 responses in EGFR-mutant lung cancer.T-B-T 淋巴细胞协作失调与 EGFR 突变型肺癌中抗 PD-1 反应不佳相关。
Nat Commun. 2021 Oct 18;12(1):6068. doi: 10.1038/s41467-021-26362-0.
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Identifying Lung Cancer Cell Markers with Machine Learning Methods and Single-Cell RNA-Seq Data.利用机器学习方法和单细胞RNA测序数据识别肺癌细胞标志物
Life (Basel). 2021 Sep 9;11(9):940. doi: 10.3390/life11090940.
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Targeted Approaches to T-Cell Lymphoma.T细胞淋巴瘤的靶向治疗方法
J Pers Med. 2021 May 27;11(6):481. doi: 10.3390/jpm11060481.
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High expression of CD52 in adipocytes: a potential therapeutic target for obesity with type 2 diabetes.脂肪细胞中 CD52 的高表达：2 型糖尿病肥胖症的潜在治疗靶点。
Aging (Albany NY). 2021 Mar 11;13(8):11043-11060. doi: 10.18632/aging.202714.
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Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection.整合单细胞分析方法研究急性 HIV-1 感染期间的多细胞免疫动力学。
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本文引用的文献

1
T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10.可溶性 CD52 通过与抑制性受体 Siglec-10 的相互作用介导 T 细胞调节。
Nat Immunol. 2013 Jul;14(7):741-8. doi: 10.1038/ni.2610. Epub 2013 May 19.
2
Generation and expansion of regulatory human CD4(+) T-cell clones specific for pancreatic islet autoantigens.生成和扩增特异性针对胰岛自身抗原的调节性人 CD4(+) T 细胞克隆。
J Autoimmun. 2011 Feb;36(1):47-55. doi: 10.1016/j.jaut.2010.10.005. Epub 2010 Nov 2.
3
Upregulating CD4+CD25+FOXP3+ regulatory T cells in pancreatic lymph nodes in diabetic NOD mice by adjuvant immunotherapy.通过辅助免疫疗法上调糖尿病NOD小鼠胰腺淋巴结中的CD4+CD25+FOXP3+调节性T细胞。
Transplantation. 2009 Jan 27;87(2):198-206. doi: 10.1097/TP.0b013e3181933261.
4
Human regulatory T cells: a unique, stable thymic subset or a reversible peripheral state of differentiation?人类调节性T细胞：一种独特、稳定的胸腺亚群还是一种可逆的外周分化状态？
Immunol Lett. 2007 Nov 30;114(1):9-15. doi: 10.1016/j.imlet.2007.08.012. Epub 2007 Sep 29.
5
From vanilla to 28 flavors: multiple varieties of T regulatory cells.从普通型到28种亚型：调节性T细胞的多种变体
Immunity. 2006 Aug;25(2):195-201. doi: 10.1016/j.immuni.2006.08.003.
6
CD52 is a novel costimulatory molecule for induction of CD4+ regulatory T cells.CD52是一种用于诱导CD4+调节性T细胞的新型共刺激分子。
Clin Immunol. 2006 Sep;120(3):247-59. doi: 10.1016/j.clim.2006.05.006. Epub 2006 Jun 22.
7
CD4+ Tregs and immune control.CD4 + 调节性T细胞与免疫控制
J Clin Invest. 2004 Nov;114(9):1209-17. doi: 10.1172/JCI23395.
8
Free circulating soluble CD52 as a tumor marker in chronic lymphocytic leukemia and its implication in therapy with anti-CD52 antibodies.游离循环可溶性CD52作为慢性淋巴细胞白血病的肿瘤标志物及其在抗CD52抗体治疗中的意义。
Cancer. 2004 Sep 1;101(5):999-1008. doi: 10.1002/cncr.20477.
9
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes.体外扩增的抗原特异性调节性T细胞可抑制自身免疫性糖尿病。
J Exp Med. 2004 Jun 7;199(11):1455-65. doi: 10.1084/jem.20040139.
10
CD4(+) T cells from glutamic acid decarboxylase (GAD)65-specific T cell receptor transgenic mice are not diabetogenic and can delay diabetes transfer.来自谷氨酸脱羧酶（GAD）65特异性T细胞受体转基因小鼠的CD4（+）T细胞不具有致糖尿病性，并且可以延缓糖尿病的转移。
J Exp Med. 2002 Aug 19;196(4):481-92. doi: 10.1084/jem.20011845.

CD52 as both a marker and an effector molecule of T cells with regulatory action: Identification of novel regulatory T cells.

作者信息

Samten Buka

出版信息

Cell Mol Immunol. 2013 Nov;10(6):456-8. doi: 10.1038/cmi.2013.38. Epub 2013 Sep 16.

DOI:10.1038/cmi.2013.38
PMID:24037183
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4002393/
Abstract
摘要