Honar Naser, Karamizadeh Zohreh, Saki Forough
Shiraz Medical University, Department of Pediatrics, Shiraz, Islamic Republic of Iran.
Turk J Gastroenterol. 2013;24(2):122-6. doi: 10.4318/tjg.2013.0541.
BACKGROUND/AIMS: Celiac disease is a chronic enteropathy caused by hypersensitivity to gluten. An increased prevalence of celiac disease has been found in children with diabetes mellitus type 1. The large differences in the frequency of celiac disease in different countries show a great regional variability. Our aim was to detect the prevalence of celiac disease in diabetes mellitus type 1 children among southern Iranians.
A prospective study was conducted on 83 diabetes mellitus type 1 children from the south of Iran. They were tested for the presence of anti-tissue transglutaminase immunoglobulin A antibody and total immunoglobulin A level. The patients testing immunoglobulin A anti-tissue transglutaminase-positive were offered small bowel biopsy.
Eighty-three children with diabetes mellitus type 1 (49 females, 34 males) aged 10.38±4.7 years were enrolled. None of the patients was immunoglobulin A deficient. Twelve diabetic children had a high titer of anti-tissue transglutaminase immunoglobulin A (14.4%). In four patients, biopsy was in favor of celiac disease (4.8%).
Our study showed that the prevalence of celiac disease in diabetes mellitus type 1 children in Iran is more than in America and Europe but similar to that observed in Turkey. The age of the patient and duration of disease had an effect on this prevalence, and more studies should be done to determine the effects of ethnic, genetic and environmental factors such as diet to identify the reasons for these differences.
背景/目的：乳糜泻是一种由对麸质过敏引起的慢性肠病。1型糖尿病患儿中乳糜泻的患病率有所增加。不同国家乳糜泻发病率的巨大差异显示出很大的地区变异性。我们的目的是检测伊朗南部1型糖尿病患儿中乳糜泻的患病率。
对来自伊朗南部的83名1型糖尿病患儿进行了一项前瞻性研究。检测他们是否存在抗组织转谷氨酰胺酶免疫球蛋白A抗体和总免疫球蛋白A水平。对免疫球蛋白A抗组织转谷氨酰胺酶检测呈阳性的患者进行小肠活检。
纳入了83名1型糖尿病患儿（49名女性，34名男性），年龄为10.38±4.7岁。所有患者均无免疫球蛋白A缺乏。12名糖尿病患儿抗组织转谷氨酰胺酶免疫球蛋白A滴度较高（14.4%）。4名患者的活检结果支持乳糜泻（4.8%）。
我们的研究表明，伊朗1型糖尿病患儿中乳糜泻的患病率高于美国和欧洲，但与土耳其观察到的患病率相似。患者年龄和病程对该患病率有影响，应开展更多研究以确定种族、遗传和环境因素（如饮食）的影响，从而找出这些差异的原因。
