N1-取代乳清酸衍生物的改进合成方法。
Improved synthesis of N1-substituted orotic acid derivatives.
作者信息
Senger Nicholas A, Bowler Jeannette T, Mercado Rene S, Lin Sidney, Wu Weiming
机构信息
Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA 94132 USA.
出版信息
Tetrahedron Lett. 2013 Aug 7;54(32):4245-4246. doi: 10.1016/j.tetlet.2013.05.136.
Abstract
An improved method for the synthesis of N1-substituted orotic acid derivatives is reported. The method involves sequential incorporation of nitrogen atoms to the pyrimidine structure from simple starting materials and thus allows the synthesis of N1-substituted orotic acid derivatives with single N label at either N-1 or N-3.
摘要
报道了一种合成N1-取代乳清酸衍生物的改进方法。该方法涉及从简单的起始原料将氮原子依次引入嘧啶结构，从而能够合成在N-1或N-3处带有单个N标记的N1-取代乳清酸衍生物。
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引用本文的文献
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Convenient synthesis of N1-substituted orotic acid derivatives.N1-取代乳清酸衍生物的简便合成
Tetrahedron Lett. 2014 Nov 19;55(47):6465-6466. doi: 10.1016/j.tetlet.2014.10.005.
本文引用的文献
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Stabilities of Uracil and Pyridone-Based Carbanions: A Systematic Study in the Gas Phase and Solution and Implications for the Mechanism of Orotidine-5'-Monophosphate Decarboxylase.尿嘧啶和吡啶酮基碳负离子的稳定性：气相和溶液中的系统研究以及对乳清苷 -5'- 单磷酸脱羧酶作用机制的启示
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