Bao Dang-Zhen, Bao Huan-Ying, Yao Li-Zhai, Pan Yun-Gao, Zhu Xin-Rui, Yang Xiao-Song, Wang He, Huang Yi-Ning
Department of Neurology, Nanle Rehabilitation Hospital, Puyang, Henan 457400;
Exp Ther Med. 2013 Jul;6(1):133-139. doi: 10.3892/etm.2013.1107. Epub 2013 May 9.
The aim of this study was to determine the value of computed tomography perfusion (CTP) parameters, including cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT) and time-to-peak (TP), in a clinical study of patients with stroke. Additionally, we determined which parameter or combination of parameters are reliable in detecting the presence of an infarct and penumbra. CTP was performed within 24 h of the onset of symptoms in 20 patients with possible stroke. Magnetic resonance imaging (MRI) was performed 3-7 days later and the threshold of the CTP was adjusted according to the results to provide CT images that correlated with the MRI; the MRI results were taken as the gold standard. CBV, CBF and TP contrast agent enhancement were calculated using the CT results. The CTP results were compared with the MRI findings. All CTP parameters were reliable in detecting the penumbra (P<0.001). In these parameters, changes of MTT were the most useful. CTP revealed various changes in CBF, CBV, MTT and TP in ischemic areas. CTP parameters were also reliable in detecting the infarct core (P<0.001). We determined that when detecting the penumbra, all CTP parameters are reliable, and when detecting cerebral ischemia, a combination of parameters should be used.
本研究的目的是在一项针对中风患者的临床研究中，确定计算机断层扫描灌注（CTP）参数的价值，这些参数包括脑血流量（CBF）、脑血容量（CBV）、平均通过时间（MTT）和达峰时间（TP）。此外，我们还确定了哪些参数或参数组合在检测梗死灶和半暗带的存在方面是可靠的。对20例可能发生中风的患者在症状发作后24小时内进行了CTP检查。3至7天后进行了磁共振成像（MRI）检查，并根据结果调整CTP的阈值，以提供与MRI相关的CT图像；MRI结果被视为金标准。使用CT结果计算CBV、CBF和TP造影剂增强。将CTP结果与MRI结果进行比较。所有CTP参数在检测半暗带方面都是可靠的（P<0.001）。在这些参数中，MTT的变化最有用。CTP显示缺血区域的CBF、CBV、MTT和TP有各种变化。CTP参数在检测梗死核心方面也是可靠的（P<0.001）。我们确定，在检测半暗带时，所有CTP参数都是可靠的，而在检测脑缺血时，应使用参数组合。
