Cochran M, Wilkinson R
Nephron. 1975;15(2):98-110. doi: 10.1159/000180501.
The role of metabolic acidosis in the genesis of renal osteomalacia was investigated by studying bone mineralisation and resorption rates with a combined isotope and balance technique in six patients, before and after the administration of alkali. Correction of blood pH was achieved in five cases and was associated with a significant rise in the bone mineralisation rates and a significant positive trend in the calcium balances. It is suggested that acidosis contributes to the pathogenesis of osteomalacia in renal failure by slowing skeletal mineralisation, possibly by inhibiting bone alkaline phosphatase.
通过联合使用同位素和平衡技术研究6例患者在服用碱剂前后的骨矿化和吸收速率，探讨代谢性酸中毒在肾性骨软化症发生中的作用。5例患者的血液pH值得到纠正，同时骨矿化速率显著升高，钙平衡呈显著正向变化趋势。提示酸中毒可能通过抑制骨碱性磷酸酶从而减缓骨骼矿化，进而促使肾衰竭患者发生骨软化症。
