Department of Digestive Diseases, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, PR China.
PLoS One. 2013 Jul 31;8(7):e68588. doi: 10.1371/journal.pone.0068588. Print 2013.
Previous studies have focused on the association of miR-34 family members with carcinogenesis of many cancers, including hepatocellular carcinoma (HCC). It has been suggested that miR-34b/c polymorphism (rs4938723) is associated with susceptibility to HCC. In the present study, we performed a meta-analysis to systematically summarize the possible association between rs4938723 and the risk for HCC.
METHODOLOGY/PRINCIPAL FINDINGS: We conducted a search of case-control studies on the associations of rs4938723 with susceptibility to HCC in PubMed, EMBASE, ISI Web of Science, Cochrane Central Register of Controlled Trials, ScienceDirect, Wiley Online Library, Wangfang database in China, and Chinese National Knowledge Infrastructure databases. Data from eligible studies were extracted for meta-analysis. HCC risk associated with rs4938723 was estimated by pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). 3 studies on rs4938723 were included in our meta-analysis. Our results showed that neither allele frequency nor genotype distribution of the rs4938723 was associated with risk for HCC in all genetic models.
CONCLUSIONS/SIGNIFICANCE: This meta-analysis suggests that rs4938723 is not associated with the risk of HCC. Well-designed studies with larger sample size and more ethnic groups are required to further validate the results.
先前的研究集中在 miR-34 家族成员与包括肝细胞癌（HCC）在内的多种癌症的致癌作用的关联上。有研究表明，miR-34b/c 多态性（rs4938723）与 HCC 的易感性有关。在本研究中，我们进行了一项荟萃分析，以系统总结 rs4938723 与 HCC 风险之间可能存在的关联。
方法/主要发现：我们在 PubMed、EMBASE、ISI Web of Science、Cochrane 对照试验中心注册库、ScienceDirect、Wiley Online Library、中国万方数据库和中国国家知识基础设施数据库中对 rs4938723 与 HCC 易感性相关的病例对照研究进行了检索。对合格研究的数据进行了荟萃分析。通过汇总优势比（OR）和 95%置信区间（95%CI）来估计 rs4938723 与 HCC 风险的相关性。我们的荟萃分析纳入了 3 项关于 rs4938723 的研究。结果表明，在所有遗传模型中，rs4938723 的等位基因频率和基因型分布均与 HCC 风险无关。
结论/意义：本荟萃分析表明，rs4938723 与 HCC 的风险无关。需要设计更好、样本量更大且包含更多种族群体的研究来进一步验证这些结果。
