Duan Chen-Yang, Liu Meng-Ying, Li Shao-bo, Ma Kuan-sheng, Bie Ping
Company Five of Cadet Brigade, Third Military Medical University, Chongqing, 400038, China.
Tumour Biol. 2014 Jan;35(1):659-66. doi: 10.1007/s13277-013-1090-7. Epub 2013 Aug 17.
Previous studies have focused on the association of a gene (EPHX1) encoding microsomal epoxide hydrolase with the carcinogenesis of hepatocellular carcinoma (HCC). In the present study, we performed a meta-analysis to systematically summarize the possible association between EPHX1 genetic polymorphisms and the risk for HCC. We conducted a search of case-control studies on the associations of EPHX1 genetic polymorphisms with susceptibility to HCC in PubMed, EMBASE, ISI Web of Science, Wanfang database in China, and the Chinese National Knowledge Infrastructure databases. Data from eligible studies were extracted for meta-analysis. HCC risk associated with EPHX1 genetic polymorphism was estimated by pooled odds ratios and 95% confidence intervals. Thirteen studies were included in the present meta-analysis. Our results showed that, for the two polymorphisms (337 T > C and 416A > G) of EPHX1 gene, neither allele frequency nor genotype distributions were associated with risk for HCC in all genetic models (all P > 0.05). This meta-analysis suggests that EPHX1 genetic polymorphisms were not associated with the risk of HCC.
以往的研究主要聚焦于编码微粒体环氧化物水解酶的基因（EPHX1）与肝细胞癌（HCC）发生之间的关联。在本研究中，我们进行了一项荟萃分析，以系统总结EPHX1基因多态性与HCC风险之间可能存在的关联。我们在PubMed、EMBASE、ISI科学网、中国万方数据库和中国知网数据库中检索了关于EPHX1基因多态性与HCC易感性关联的病例对照研究。提取符合条件的研究数据进行荟萃分析。通过合并比值比和95%置信区间来估计与EPHX1基因多态性相关的HCC风险。本荟萃分析纳入了13项研究。我们的结果显示，对于EPHX1基因的两个多态性位点（337T>C和416A>G），在所有遗传模型中，等位基因频率和基因型分布均与HCC风险无关（所有P>0.05）。这项荟萃分析表明，EPHX1基因多态性与HCC风险无关。
