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实验性棘阿米巴角膜炎：I. 初步研究结果。

Experimental Acanthamoeba keratitis: I. Preliminary findings.

作者信息

Larkin D F, Easty D L

机构信息

Department of Ophthalmology, Bristol Eye Hospital.

出版信息

Br J Ophthalmol. 1990 Sep;74(9):551-5. doi: 10.1136/bjo.74.9.551.

DOI:10.1136/bjo.74.9.551
PMID:2393646
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1042207/
Abstract

Experimental Acanthamoeba keratitis was induced in Wistar rats by intrastromal inoculation of Acanthamoeba polyphaga cysts. Keratitis developed in all corneas injected and was characterised by a diffuse granular opacity. The animals were examined for 70 days and a gradual reduction of keratitis was observed. Pathological sections showed liquefactive stromal necrosis and Acanthamoeba localised in deep stroma persisting to 70 days. A brisk inflammatory infiltrate of neutrophils and macrophages was seen in the early days of infection. Severity of keratitis was found to correlate with inflammatory activity in pathological sections. The uses of an animal model of Acanthamoeba keratitis are described.

摘要

通过基质内接种多食棘阿米巴囊肿在Wistar大鼠中诱发实验性棘阿米巴角膜炎。所有注射的角膜均发生角膜炎，其特征为弥漫性颗粒状混浊。对动物进行了70天的检查，观察到角膜炎逐渐减轻。病理切片显示液化性基质坏死，棘阿米巴位于深层基质中，持续至70天。在感染初期可见中性粒细胞和巨噬细胞的活跃炎性浸润。发现角膜炎的严重程度与病理切片中的炎症活动相关。描述了棘阿米巴角膜炎动物模型的用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89a3/1042207/4e85914057d1/brjopthal00583-0045-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89a3/1042207/be22d9c2ac0c/brjopthal00583-0043-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89a3/1042207/50d0a5f34b39/brjopthal00583-0044-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89a3/1042207/4c6db74a7934/brjopthal00583-0044-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89a3/1042207/8984eef40bd5/brjopthal00583-0045-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89a3/1042207/4e85914057d1/brjopthal00583-0045-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89a3/1042207/be22d9c2ac0c/brjopthal00583-0043-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89a3/1042207/50d0a5f34b39/brjopthal00583-0044-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89a3/1042207/4c6db74a7934/brjopthal00583-0044-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89a3/1042207/8984eef40bd5/brjopthal00583-0045-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89a3/1042207/4e85914057d1/brjopthal00583-0045-b.jpg

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Acanthamoeba keratitis successfully treated with penetrating keratoplasty: suggested immunogenic mechanisms of action.穿透性角膜移植术成功治疗棘阿米巴角膜炎：作用的免疫原性机制探讨
Cornea. 1984;3(2):125-30.
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Taxonomic criteria for limax amoebae, with descriptions of 3 new species of Hartmannella and 3 of Vahlkampfia.蛞蝓变形虫的分类标准，以及3个新种哈特曼变形虫和3个新种瓦氏变形虫的描述。
属于T4基因型的棘阿米巴的致病性检测
Iran J Parasitol. 2013 Oct;8(4):530-5.
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Role of the corneal epithelial basement membrane in ocular defense against Pseudomonas aeruginosa.角膜上皮基底膜在眼部抵御铜绿假单胞菌中的作用。
Infect Immun. 2009 Aug;77(8):3264-71. doi: 10.1128/IAI.00111-09. Epub 2009 Jun 8.
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Clin Microbiol Rev. 2003 Apr;16(2):273-307. doi: 10.1128/CMR.16.2.273-307.2003.
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The immunobiology of Acanthamoeba keratitis.棘阿米巴角膜炎的免疫生物学
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