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穿透性角膜移植术成功治疗棘阿米巴角膜炎:作用的免疫原性机制探讨

Acanthamoeba keratitis successfully treated with penetrating keratoplasty: suggested immunogenic mechanisms of action.

作者信息

Blackman H J, Rao N A, Lemp M A, Visvesvara G S

出版信息

Cornea. 1984;3(2):125-30.

PMID:6399233
Abstract

A patient with a corneal ulcer caused by Acanthamoeba polyphaga has been successfully treated with a penetrating keratoplasty. The pathologic specimen showed no inflammatory infiltrate surrounding the intact amoeba, whereas necrotic organisms were surrounded by an intense cellular reaction. Indirect immunochemical studies showed that the trophozoite stained profusely, but the cyst form exhibited the antigenic site on the cyst wall.

摘要

一名由多食棘阿米巴引起角膜溃疡的患者已通过穿透性角膜移植术成功治愈。病理标本显示完整的阿米巴周围无炎性浸润,而坏死的病原体周围有强烈的细胞反应。间接免疫化学研究表明,滋养体染色丰富,但包囊形式在包囊壁上显示出抗原位点。

相似文献

1
Acanthamoeba keratitis successfully treated with penetrating keratoplasty: suggested immunogenic mechanisms of action.穿透性角膜移植术成功治疗棘阿米巴角膜炎:作用的免疫原性机制探讨
Cornea. 1984;3(2):125-30.
2
Cryotherapy for medically unresponsive acanthamoeba keratitis.针对药物治疗无效的棘阿米巴角膜炎的冷冻疗法。
Cornea. 1989;8(2):106-14.
3
Acanthamoeba keratitis. A review of the literature.棘阿米巴角膜炎。文献综述。
Cornea. 1987;6(1):2-26.
4
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 10-1985. A 29-year-old native of India with bilateral ulcerative keratitis.
N Engl J Med. 1985 Mar 7;312(10):634-41. doi: 10.1056/NEJM198503073121007.
5
Immunopathology and electron microscopy of Acanthamoeba keratitis.
Am J Ophthalmol. 1987 May 15;103(5):626-35. doi: 10.1016/s0002-9394(14)74321-1.
6
[Acanthamoeba keratitis--a too seldom diagnosed disease?].[棘阿米巴角膜炎——一种诊断过少的疾病?]
Klin Monbl Augenheilkd. 1989 Jun;194(6):454-7. doi: 10.1055/s-2008-1046400.
7
[Corneal covering of cornea in ulcerative keratitis: clinical and histological observations (author's transl)].[溃疡性角膜炎角膜的角膜覆盖:临床与组织学观察(作者译)]
Klin Monbl Augenheilkd. 1978 Aug;173(2):237-43.
8
[Keratoplasty in infected corneal wounds].[感染性角膜伤口的角膜移植术]
Oftalmol Zh. 1978;33(2):96-100.
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Acanthamoeba keratitis possibly acquired from a hot tub.棘阿米巴角膜炎可能是由热水浴缸感染所致。
Arch Ophthalmol. 1984 May;102(5):707-10. doi: 10.1001/archopht.1984.01040030563018.
10
[Keratoplasty à chaud as a therapeutic measure in acute corneal infections].[热角膜移植术作为急性角膜感染的一种治疗措施]
Klin Monbl Augenheilkd. 1984 Jun;184(6):520-8. doi: 10.1055/s-2008-1054544.

引用本文的文献

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The Natural History of Acanthamoeba Keratitis: A Systematic Literature Review.棘阿米巴角膜炎的自然史:一项系统文献综述
Ophthalmol Ther. 2025 May 5. doi: 10.1007/s40123-025-01152-9.
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The role of naturally acquired intracellular Pseudomonas aeruginosa in the development of Acanthamoeba keratitis in an animal model.在动物模型中,天然获得的细胞内铜绿假单胞菌在棘阿米巴角膜炎发展中的作用。
PLoS Negl Trop Dis. 2024 Jan 2;18(1):e0011878. doi: 10.1371/journal.pntd.0011878. eCollection 2024 Jan.
3
Diagnosis of Keratitis: Past, Present and Future.
角膜炎的诊断:过去、现在与未来
Diagnostics (Basel). 2023 Aug 11;13(16):2655. doi: 10.3390/diagnostics13162655.
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Non-contact lens related keratitis.非隐形眼镜相关性角膜炎
Indian J Ophthalmol. 2017 Nov;65(11):1079-1086. doi: 10.4103/ijo.IJO_826_17.
5
An update on Acanthamoeba keratitis: diagnosis, pathogenesis and treatment.棘阿米巴角膜炎的最新进展:诊断、发病机制与治疗
Parasite. 2015;22:10. doi: 10.1051/parasite/2015010. Epub 2015 Feb 18.
6
Characterisation and differentiation of pathogenic and non-pathogenic Acanthamoeba strains by their protein and antigen profiles.通过蛋白质和抗原谱对致病性和非致病性棘阿米巴菌株进行表征和鉴别。
Parasitol Res. 2004 Mar;92(4):289-98. doi: 10.1007/s00436-003-1041-0. Epub 2004 Jan 13.
7
Persistence of acanthamoeba antigen following acanthamoeba keratitis.棘阿米巴角膜炎后棘阿米巴抗原的持续存在。
Br J Ophthalmol. 2001 Mar;85(3):277-80. doi: 10.1136/bjo.85.3.277.
8
Experimental Acanthamoeba keratitis: I. Preliminary findings.实验性棘阿米巴角膜炎:I. 初步研究结果。
Br J Ophthalmol. 1990 Sep;74(9):551-5. doi: 10.1136/bjo.74.9.551.