黑素细胞在伤口愈合过程中对病理性瘢痕形成的作用。
The contribution of melanocytes to pathological scar formation during wound healing.
作者信息
Gao Fu-Lei, Jin Rong, Zhang Lu, Zhang Yu-Guang
机构信息
Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China 200011.
出版信息
Int J Clin Exp Med. 2013 Aug 1;6(7):609-13. Print 2013.
Abstract
Both hypertrophic scars and keloid scars are caused by abnormal wound healing, the key feature of which is excess collagen fiber secretion by fibroblasts. Many different factors could affect the process of hypertrophic scar and keloid formation, but most have not been identified to date. We assume that, during wound healing, melanocytes from the stratum basale contact or interact with fibroblasts from the dermal layers after the basal membrane is damaged, which in turn facilitates fibroblast proliferation and the secretion and deposition of collagen. This plays a significant role in the generation of hypertrophic scars and keloids.
摘要
肥厚性瘢痕和瘢痕疙瘩均由异常伤口愈合引起，其关键特征是成纤维细胞分泌过多的胶原纤维。许多不同因素可影响肥厚性瘢痕和瘢痕疙瘩的形成过程，但迄今为止大多数因素尚未明确。我们推测，在伤口愈合过程中，基底膜受损后，基底层的黑素细胞与真皮层的成纤维细胞接触或相互作用，进而促进成纤维细胞增殖以及胶原的分泌和沉积。这在肥厚性瘢痕和瘢痕疙瘩的形成中起重要作用。
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