Department of Physiology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Charlie Norwood VA Medical Center, Augusta, GA 30904, USA.
Int J Mol Sci. 2024 Mar 28;25(7):3790. doi: 10.3390/ijms25073790.
Cutaneous wound healing is a complex biological process involving a series of well-coordinated events aimed at restoring skin integrity and function. Various experimental models have been developed to study the mechanisms underlying skin wound repair and to evaluate potential therapeutic interventions. This review explores the diverse array of skin wound healing models utilized in research, ranging from rodent excisional wounds to advanced tissue engineering constructs and microfluidic platforms. More importantly, the influence of lipids on the wound healing process is examined, emphasizing their role in enhancing barrier function restoration, modulating inflammation, promoting cell proliferation, and promoting remodeling. Lipids, such as phospholipids, sphingolipids, and ceramides, play crucial roles in membrane structure, cell signaling, and tissue repair. Understanding the interplay between lipids and the wound microenvironment provides valuable insights into the development of novel therapeutic strategies for promoting efficient wound healing and tissue regeneration. This review highlights the significance of investigating skin wound healing models and elucidating the intricate involvement of lipids in the healing process, offering potential avenues for improving clinical outcomes in wound management.
皮肤创伤愈合是一个复杂的生物学过程，涉及一系列协调良好的事件，旨在恢复皮肤的完整性和功能。已经开发了各种实验模型来研究皮肤创伤修复的机制，并评估潜在的治疗干预措施。本综述探讨了在研究中使用的各种皮肤创伤愈合模型，从啮齿动物的切除性创伤到先进的组织工程构建体和微流控平台。更重要的是，研究了脂质对创伤愈合过程的影响，强调了它们在增强屏障功能恢复、调节炎症、促进细胞增殖和促进重塑方面的作用。脂质，如磷脂、鞘脂和神经酰胺，在膜结构、细胞信号转导和组织修复中发挥着关键作用。了解脂质与创伤微环境之间的相互作用为开发促进有效创伤愈合和组织再生的新型治疗策略提供了有价值的见解。本综述强调了研究皮肤创伤愈合模型和阐明脂质在愈合过程中的复杂作用的重要性，为改善创伤管理中的临床结果提供了潜在途径。
