Bartolozzi C, Lencioni R, Caramella D, Vignali C, Cioni R, Mazzeo S, Carrai M, Maltinti G, Capria A, Conte P F
Department of Radiology, Santa Chiara University Hospital, Pisa, Italy.
Radiology. 1995 Dec;197(3):812-8. doi: 10.1148/radiology.197.3.7480761.
To compare the efficacy of transcatheter arterial chemoembolization (TACE) combined with percutaneous ethanol injection (PEI) versus repeated TACE in the treatment of large hepatocellular carcinoma (HCC).
Fifty-three patients with cirrhosis and a large HCC (main tumor, 3.1-8.0 cm in diameter with no more than two daughter nodules) were enrolled in a prospective, randomized study. Twenty-six patients underwent a single TACE session followed by PEI (TACE-PEI group), whereas 27 patients underwent two to five TACE sessions (TACE group). Both groups of patients were similar with regard to liver function. Follow-up ranged from 8 to 39 months.
Complete therapeutic responses were higher (P < .05) and tumor recurrences during follow-up were lower (P < .05) in the TACE-PEI group than in the TACE group. Patients in the TACE-PEI group survived longer than those in the TACE group, although the difference was not significant (P > .1). The rates of survival without recurrence were better in the TACE-PEI group than in the TACE group (P < .05).
Use of a single TACE session combined with PEI is more effective than repeated TACE in the treatment of large HCC.
比较经导管动脉化疗栓塞术（TACE）联合经皮乙醇注射（PEI）与重复TACE治疗大肝癌（HCC）的疗效。
53例肝硬化合并大肝癌患者（主瘤直径3.1 - 8.0 cm，子结节不超过2个）纳入一项前瞻性随机研究。26例患者接受单次TACE治疗后行PEI（TACE-PEI组），而27例患者接受2至5次TACE治疗（TACE组）。两组患者的肝功能相似。随访时间为8至39个月。
TACE-PEI组的完全治疗反应率更高（P <.05），随访期间肿瘤复发率更低（P <.05）。TACE-PEI组患者的生存期比TACE组长，尽管差异不显著（P >.1）。TACE-PEI组无复发生存率优于TACE组（P <.05）。
单次TACE联合PEI治疗大肝癌比重复TACE更有效。
