Peake Philip, Colagiuri Stephen, Campbell Lesley V, Shen Yvonne
Renal Laboratory, Department of Medicine, University of New South Wales, Randwick, NSW 2031, Australia.
ISRN Endocrinol. 2013 Jul 9;2013:873507. doi: 10.1155/2013/873507. Print 2013.
Aim. Adiponectin has demonstrated anti-inflammatory and insulin sensitising properties, and low circulating levels may be an important risk factor for diabetes. We examined levels of adiponectin and its insulin-sensitising HMW isoform and their relationship with metabolic parameters in Tongans, a population prone to type II diabetes. Methods. Adiponectin and its HMW isoform were quantitated by Elisa in specimens from a randomly recruited, multistage cluster population survey of Tongans and from a group of Caucasians. Anthropometric, clinical, and biochemical data were collected on each subject. Results. Both male and female Tongans had lower levels of total and HMW adiponectin than their Caucasian counterparts. Levels of total and HMW adiponectin were higher in females than males in each group. Adiponectin levels were inversely related to BMI, weight, and HOMA in Tongan males and females, as well as to dyslipidemia in both sexes. Conclusion. Tongans had lower levels of both total and HMW adiponectin than Caucasians population, even after matching Tongans to their Caucasian counterparts based on BMI, age, and sex. These findings may reflect differences in body composition between the populations not adequately assessed by BMI, lifestyle factors, or a genetic variant likely in a genetically homogenous population.
目的。脂联素已显示出抗炎和胰岛素增敏特性，而循环水平低可能是糖尿病的一个重要危险因素。我们研究了汤加人（一个易患II型糖尿病的人群）中脂联素及其胰岛素增敏高分子量异构体的水平，以及它们与代谢参数的关系。方法。通过酶联免疫吸附测定法（ELISA）对从随机招募的汤加人多阶段整群人群调查样本以及一组高加索人样本中的脂联素及其高分子量异构体进行定量分析。收集了每个受试者的人体测量学、临床和生化数据。结果。汤加男性和女性的总脂联素和高分子量脂联素水平均低于其高加索人对应者。每组中女性的总脂联素和高分子量脂联素水平均高于男性。在汤加男性和女性中，脂联素水平与体重指数（BMI）、体重和稳态模型评估胰岛素抵抗（HOMA）呈负相关，在两性中也与血脂异常呈负相关。结论。即使根据BMI、年龄和性别将汤加人与他们的高加索人对应者进行匹配后，汤加人的总脂联素和高分子量脂联素水平仍低于高加索人群。这些发现可能反映了人群之间身体组成的差异，而BMI、生活方式因素或在基因同质人群中可能存在的基因变异未能充分评估这种差异。
