Department of Cardiovascular and Renal Medicine, Saga University, Japan.
J Atheroscler Thromb. 2009 Oct;16(5):553-9. doi: 10.5551/jat.1073.
Low plasma adiponectin levels have been demonstrated to be linked to obesity and insulin resistance. It has also been suggested that high molecular weight (HMW) adiponectin is more important for vascular protection than the total amount of adiponectin, although clinical data of HMW adiponectin are lacking. The purpose of this study was to investigate HMW adiponectin levels in Japanese rural residents and to elucidate their clinical significance.
We measured plasma HMW adiponectin levels in 1,183 subjects (643 men) who participated in our annual health check program in Kashima-city, Saga, Japan.
The median plasma level of HMW adiponectin was significantly lower in men than women (2.6, 1.64.0 vs 6.5, 3.78.6 microg/mL, p<0.001), respectively. Multivariate linear regression analysis showed that body weight, B-type natriuretic peptide (BNP) and high density lipoprotein cholesterol were independently associated with HMW adiponectin in both genders. Triglyceride and serum creatinine levels were associated with HMW adiponectin in men only.
HMW adiponectin levels were lower in men than in women and were associated with BNP independently. A prospective follow-up of the subjects in this study is required to determine the usefulness of HMW adiponectin as a biomarker for predicting the development of cardiovascular disease.
低血浆脂联素水平已被证明与肥胖和胰岛素抵抗有关。也有人认为，高分子量（HMW）脂联素对于血管保护比脂联素总量更为重要，尽管缺乏 HMW 脂联素的临床数据。本研究旨在调查日本农村居民的 HMW 脂联素水平，并阐明其临床意义。
我们测量了来自日本佐贺县鹿岛市参加年度健康检查计划的 1183 名受试者（643 名男性）的血浆 HMW 脂联素水平。
男性的血浆 HMW 脂联素中位数明显低于女性（分别为 2.6、1.64.0 和 6.5、3.78.6 microg/mL，p<0.001）。多元线性回归分析表明，体重、B 型利钠肽（BNP）和高密度脂蛋白胆固醇在两性中均与 HMW 脂联素独立相关。甘油三酯和血清肌酐水平仅与男性的 HMW 脂联素相关。
HMW 脂联素水平在男性中低于女性，与 BNP 独立相关。需要对本研究中的受试者进行前瞻性随访，以确定 HMW 脂联素作为预测心血管疾病发展的生物标志物的有用性。
