Dancker P, Hess L
Institut für Zoologie, Technische Hochschule Darmstadt, F.R.G.
Biochim Biophys Acta. 1990 Aug 17;1035(2):197-200. doi: 10.1016/0304-4165(90)90116-e.
Phalloidin, an actin-filament stabilizing peptide from Amanita phalloides, did not inhibit ATP hydrolysis during actin polymerization but strongly retarded the release of the hydrolysis product Pi. Thus, the lifetime of the intermediate F-actin-ADP-Pi is significantly increased by phalloidin. The results suggest a close correlation between filament stability and F-actin-ADP-Pi intermediates.
鬼笔环肽是一种来自毒蝇伞的肌动蛋白丝稳定肽，在肌动蛋白聚合过程中不抑制ATP水解，但强烈阻碍水解产物Pi的释放。因此，鬼笔环肽显著延长了中间产物F-肌动蛋白-ADP-Pi的寿命。结果表明细丝稳定性与F-肌动蛋白-ADP-Pi中间产物之间存在密切关联。
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