Department of Medicine, Nassau University Medical Center, East Meadow, NY 11554, USA.
Aging Dis. 2013 Mar 6;4(4):210-20. Print 2013 Aug.
Alzheimer's disease (AD) is a growing health care epidemic. It is the most common cause of dementia and its incidence is rising. Age, which influences the oxidative and inflammatory states of the brain, is the most important risk factor. Currently there is no disease modifying treatments available for this irreversible, progressive debilitating disease. Immunotherapy represents an emerging, potentially disease modifying strategy aimed at reducing the pathological lesions of AD and facilitating cognitive improvement. Many clinical trials are currently underway. This literature review highlights current knowledge regarding the physiology of aging and how it relates to the pathogenesis of AD. In addition, immunotherapy is discussed in the context of its mechanism, current studies and future goals.
阿尔茨海默病（AD）是一种日益严重的健康危机。它是痴呆症的最常见病因，其发病率正在上升。年龄是影响大脑氧化和炎症状态的最重要危险因素。目前，对于这种不可逆转、进行性衰弱的疾病，尚无有效的治疗方法。免疫疗法是一种新兴的、有潜力的疾病修饰策略，旨在减少 AD 的病理损伤并促进认知改善。目前有许多临床试验正在进行。本文综述了关于衰老生理学及其与 AD 发病机制关系的现有知识。此外，还讨论了免疫疗法的作用机制、当前研究和未来目标。
