Centre for Advanced Hybrid Materials, Department of Materials Engineering, Monash University, Clayton, VIC 3800, Australia.
Biomed Res Int. 2013;2013:914764. doi: 10.1155/2013/914764. Epub 2013 Jul 2.
The effect of grain refinement of commercial purity titanium by equal channel angular pressing (ECAP) on its mechanical performance and bone tissue regeneration is reported. In vivo studies conducted on New Zealand white rabbits did not show an enhancement of biocompatibility of ECAP-modified titanium found earlier by in vitro testing. However, the observed combination of outstanding mechanical properties achieved by ECAP without a loss of biocompatibility suggests that this is a very promising processing route to bioimplant manufacturing. The study thus supports the expectation that commercial purity titanium modified by ECAP can be seen as an excellent candidate material for bone implants suitable for replacing conventional titanium alloy implants.
商业纯钛通过等径角挤压（ECAP）细化晶粒对其力学性能和骨组织再生的影响。对新西兰白兔进行的体内研究并未显示出体外测试中早期发现的 ECAP 改性钛的生物相容性增强。然而，观察到 ECAP 在不损失生物相容性的情况下实现优异力学性能的组合表明，这是一种非常有前途的生物植入物制造加工途径。因此，该研究支持了这样一种期望，即通过 ECAP 改性的商业纯钛可用作骨植入物的优秀候选材料，适合替代传统的钛合金植入物。
