Reddy Jagadeeswara, Nagashubha B, Reddy Mahesh, Moin Afrasim, Shivakumar H G
Department of Pharmaceutics, JSS College of Pharmacy, S.S Nagar, Mysore-570015, India.
Curr Drug Deliv. 2014;11(2):191-9. doi: 10.2174/15672018113109990053.
This paper deals with the synthesis and characterization of Ghatti gum (GG) and chitosan (CS) IPN MP prepared by emulsion-cross-linking method. Glutaraldehyde (GA) was used as a cross-linker. IPN microparticles were used to deliver (DS) Diclofenac sodium (Model anti inflammatory drug) to the intestine. IPN MP were characterized by Scanning electron microscopy (SEM), differential scanning calorimetric (DSC), Fourier Transform Infrared Spectroscopy (FTIR) and evaluated for in vitro dissolution rate. FTIR studies assessed the formation of IPN structure. The surface morphology was studied by SEM. Particle sizes ranged between 294 to 366 μm. After encapsulation into IPN microparticles DSC studies were performed to recognize the crystalline nature of drug. DS percentage encapsulation efficiency (%EE) ranged from 84.09 to 96.81%. Equilibrium swelling was performed in buffer solution (pH 7.4). In-vitro release studies indicated the dependence of drug release rates on both the amount of chitosan and GG used in grounding of microparticles. The release was extended up to 12 hrs and release rates were fitted into an empirical equation to work out the diffusion parameter which indicates a Non-Fickian release. Continuous dissolution-absorption studies were carried out using everted rat intestine for optimized formulation (F9).
本文研究了通过乳液交联法制备的瓜尔豆胶（GG）和壳聚糖（CS）互穿聚合物网络微球（IPN MP）的合成与表征。戊二醛（GA）用作交联剂。IPN微球用于将双氯芬酸钠（DS，模型抗炎药）递送至肠道。通过扫描电子显微镜（SEM）、差示扫描量热法（DSC）、傅里叶变换红外光谱（FTIR）对IPN MP进行表征，并对其体外溶出速率进行评估。FTIR研究评估了IPN结构的形成。通过SEM研究表面形态。粒径范围为294至366μm。将药物包封到IPN微球中后，进行DSC研究以识别药物的结晶性质。DS的包封效率（%EE）范围为84.09至96.81%。在缓冲溶液（pH 7.4）中进行平衡溶胀。体外释放研究表明药物释放速率取决于制备微球时壳聚糖和GG的用量。释放延长至12小时，释放速率拟合到一个经验方程中以计算扩散参数，表明为非菲克扩散释放。使用外翻大鼠肠对优化配方（F9）进行连续溶出-吸收研究。
