Lohani Alka, Singh Garima, Bhattacharya Shiv Sankar, Verma Anurag
School of Pharmaceutical Sciences, IFTM University, Moradabad, Uttar Pradesh 244102, India.
J Drug Deliv. 2014;2014:583612. doi: 10.1155/2014/583612. Epub 2014 May 14.
Polymers have always been valuable excipients in conventional dosage forms, also have shown excellent performance into the parenteral arena, and are now capable of offering advanced and sophisticated functions such as controlled drug release and drug targeting. Advances in polymer science have led to the development of several novel drug delivery systems. Interpenetrating polymer networks (IPNs) have shown superior performances over the conventional individual polymers and, consequently, the ranges of applications have grown rapidly for such class of materials. The advanced properties of IPNs like swelling capacity, stability, biocompatibility, nontoxicity and biodegradability have attracted considerable attention in pharmaceutical field especially in delivering bioactive molecules to the target site. In the past few years various research reports on the IPN based delivery systems showed that these carriers have emerged as a novel carrier in controlled drug delivery. The present review encompasses IPNs, their types, method of synthesis, factors which affects the morphology of IPNs, extensively studied IPN based drug delivery systems, and some natural polymers widely used for IPNs.
聚合物一直是传统剂型中重要的辅料，在注射给药领域也表现出优异的性能，并且现在能够提供诸如控释和药物靶向等先进而复杂的功能。聚合物科学的进展推动了几种新型药物递送系统的开发。互穿聚合物网络（IPN）相较于传统的单一聚合物表现出更优异的性能，因此，这类材料的应用范围迅速扩大。IPN的先进特性，如溶胀能力、稳定性、生物相容性、无毒性和生物可降解性，在制药领域引起了相当大的关注，特别是在将生物活性分子递送至靶位点方面。在过去几年中，各种关于基于IPN的递送系统的研究报告表明，这些载体已成为控释药物递送中的新型载体。本综述涵盖了IPN、其类型、合成方法、影响IPN形态的因素、广泛研究的基于IPN的药物递送系统，以及一些广泛用于IPN的天然聚合物。
