Satirapod Chonthicha, Wingprawat Siripen, Jultanmas Rattiya, Rattanasiri Sasivimol, Jirawatnotai Siwanon, Choktanasiri Wicharn
Department of Obstetrics and Gynaecology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
J Obstet Gynaecol Res. 2014 Jan;40(1):96-101. doi: 10.1111/jog.12130. Epub 2013 Aug 12.
The aim of this study was to examine the effects of estradiol valerate (EV) on the thickness of clomiphene citrate (CC)-stimulated endometrium.
Thirty-four normal ovulatory women were randomized double-blindly into two groups to receive CC 100 mg/day on day 2-6 of the treatment cycle, and either vitamin B (placebo) or EV 6 mg/day on day 10-14 of the cycle. The endometrial thickness, endometrial pattern, numbers of mature follicles, and maximal diameters of preovulatory follicles were evaluated by transvaginal sonographic examination.
Thirty women completed both treatment cycles. Two other participants dropped out during the treatment due to side-effects (headache). The average endometrial thickness of the group treated with CC + placebo became slightly thinner when compared to the thickness at the baseline (9.04 vs 9.52 mm; P = 0.24). The CC + placebo and the CC + EV resulted in similar endometrial pattern, ovulation day, numbers of mature follicles, and sizes of the leading follicles before ovulation. However, an addition of EV into the CC cycle significantly increased the average endometrial thickness (10.7 mm vs 9.04 mm; P < 0.001).
We concluded that the addition of 6 mg/day EV following the CC treatment can prevent the endometrial thinning without perturbing folliculogenesis and ovulation.
本研究旨在探讨戊酸雌二醇（EV）对枸橼酸氯米芬（CC）刺激后的子宫内膜厚度的影响。
34名正常排卵女性被随机双盲分为两组，在治疗周期的第2 - 6天接受100毫克/天的CC治疗，在周期的第10 - 14天分别接受维生素B（安慰剂）或6毫克/天的EV治疗。通过经阴道超声检查评估子宫内膜厚度、子宫内膜形态、成熟卵泡数量和排卵前卵泡的最大直径。
30名女性完成了两个治疗周期。另外两名参与者在治疗期间因副作用（头痛）退出。与基线时的厚度相比，CC +安慰剂组的平均子宫内膜厚度略有变薄（9.04对9.52毫米；P = 0.24）。CC +安慰剂组和CC + EV组在子宫内膜形态、排卵日、成熟卵泡数量以及排卵前优势卵泡大小方面相似。然而，在CC周期中添加EV显著增加了平均子宫内膜厚度（10.7毫米对9.04毫米；P < 0.001）。
我们得出结论，在CC治疗后添加6毫克/天的EV可防止子宫内膜变薄，同时不干扰卵泡生成和排卵。
