* Biobehavioral Nursing, University of Washington.
Climacteric. 2014 Feb;17(1):10-22. doi: 10.3109/13697137.2013.828198. Epub 2013 Oct 29.
Although most women experience symptom clusters during the menopausal transition and early postmenopause, investigators reporting clinical trial effects for hot flushes often omit co-occurring symptoms. Our aim was to review controlled clinical trials of mind-body therapies for hot flushes and at least one other co-occurring symptom from these groups: sleep, cognitive function, mood, and pain.
An experienced reference librarian performed an extensive search of PubMed/Medline, CINAHL Plus, PsycInfo, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Web of Science, EMBASE, AMED, and Alt-Health Watch for randomized controlled trials reported in English between 2004 and July 2011. Of 1193 abstracts identified, 58 trials examining effectiveness of therapies for hot flushes and at least one additional co-occurring symptom of interest were identified.
Eight trials (ten publications) examined relaxation, yoga, or exercise. Physical activity/exercise trials (six) yielded mixed results; only one significantly reduced hot flushes and mood symptoms. Of two relaxation therapy trials, only mindfulness-based stress reduction training reduced sleep and mood symptoms and had within-group treatment effects on hot flushes. Yoga (one trial) significantly reduced hot flushes and improved cognitive symptoms more than exercise, and also had within-group effects on sleep and pain symptoms.
Studies of mind-body therapies for hot flushes increasingly measure multiple symptom outcomes, but few report treatment effects in ways that allow clinicians to consider symptom clusters when prescribing therapies. Future studies need to measure and report results for individual symptoms or group like symptoms together into subscales rather than use subscales with mixed dimensions. Trials with larger numbers of participants are essential to allow evaluation of these therapies on multiple co-occurring symptoms.
尽管大多数女性在更年期过渡和绝经早期都会经历症状群，但报告热潮红临床试验效果的研究人员经常忽略同时出现的症状。我们的目的是回顾针对热潮红和这些组中至少一种其他同时出现的症状（睡眠、认知功能、情绪和疼痛）的身心疗法的对照临床试验。
一位经验丰富的参考馆员在 2004 年至 2011 年 7 月期间，使用 PubMed/Medline、CINAHL Plus、PsycInfo、Cochrane 系统评价数据库、Cochrane 对照试验中心注册、Web of Science、EMBASE、AMED 和 Alt-Health Watch 等数据库，对以英语发表的随机对照试验进行了广泛的检索。在 1193 篇摘要中，确定了 58 项研究，这些研究检验了治疗热潮红和至少一种其他相关症状的疗法的有效性。
八项试验（十篇文献）研究了放松、瑜伽或运动。身体活动/运动试验（六项）得出了混合的结果；只有一项显著减少了热潮红和情绪症状。在两项放松治疗试验中，只有正念减压训练减少了睡眠和情绪症状，并对热潮红有组内治疗作用。瑜伽（一项试验）显著减少了热潮红，改善了认知症状，比运动更有效，并且对睡眠和疼痛症状也有组内作用。
针对热潮红的身心疗法研究越来越多地测量多种症状结果，但很少有报告以允许临床医生在开处方治疗时考虑症状群的方式报告治疗效果。未来的研究需要测量和报告单个症状或组合相似症状的结果，将其归入子量表，而不是使用具有混合维度的子量表。需要有更多参与者的试验来评估这些疗法对多种同时出现的症状的效果。
