Department of Endocrinology, School of Medicine, Stanford University, Stanford, CA, USA.
J Biosci. 2013 Sep;38(3):641-9. doi: 10.1007/s12038-013-9346-3.
Stem cell research holds a promise to treat and prevent age-related degenerative changes in humans. Literature is replete with studies showing that stem cell function declines with aging, especially in highly proliferative tissues/ organs. Among others, telomerase and telomere damage is one of the intrinsic physical instigators that drive agerelated degenerative changes. In this review we provide brief overview of telomerase-deficient aging affects in diverse stem cells populations. Furthermore, potential disease phenotypes associated with telomerase dysregulation in a specific stem cell population is also discussed in this review. Additionally, the role of telomerase in stem cell driven cancer is also briefly touched upon.
干细胞研究有望治疗和预防人类与年龄相关的退行性变化。文献中充满了研究表明，随着年龄的增长，干细胞功能下降，尤其是在高度增殖的组织/器官中。其中，端粒酶和端粒损伤是导致与年龄相关的退行性变化的内在物理诱因之一。在这篇综述中，我们简要概述了端粒酶缺陷性衰老对不同干细胞群体的影响。此外，还讨论了特定干细胞群体中端粒酶失调与潜在疾病表型的关系。此外，还简要探讨了端粒酶在干细胞驱动的癌症中的作用。
