社交焦虑障碍中预期焦虑期间的大脑激活。
Brain activation during anticipatory anxiety in social anxiety disorder.
作者信息
Boehme Stephanie, Ritter Viktoria, Tefikow Susan, Stangier Ulrich, Strauss Bernhard, Miltner Wolfgang H R, Straube Thomas
机构信息
Department of Biological and Clinical Psychology, Friedrich Schiller University Jena, Am Steiger 3/1, D-07743 Jena, Department of Clinical Psychology and Psychotherapy, Goethe-University Frankfurt, Varrentrappstr. 40-42, D-60486 Frankfurt am Main, Institute of Psychosocial Medicine and Psychotherapy, Jena University Hospital-Friedrich Schiller University, Stoystr. 3, D-07740 Jena and Institute of Medical Psychology and Systems Neuroscience, University of Muenster, Von-Esmarch-Str. 52, D-48149 Muenster, Germany
Department of Biological and Clinical Psychology, Friedrich Schiller University Jena, Am Steiger 3/1, D-07743 Jena, Department of Clinical Psychology and Psychotherapy, Goethe-University Frankfurt, Varrentrappstr. 40-42, D-60486 Frankfurt am Main, Institute of Psychosocial Medicine and Psychotherapy, Jena University Hospital-Friedrich Schiller University, Stoystr. 3, D-07740 Jena and Institute of Medical Psychology and Systems Neuroscience, University of Muenster, Von-Esmarch-Str. 52, D-48149 Muenster, Germany.
出版信息
Soc Cogn Affect Neurosci. 2014 Sep;9(9):1413-8. doi: 10.1093/scan/nst129. Epub 2013 Aug 11.
Exaggerated anticipatory anxiety during expectation of performance-related situations is an important feature of the psychopathology of social anxiety disorder (SAD). The neural basis of anticipatory anxiety in SAD has not been investigated in controlled studies. The current study used functional magnetic resonance imaging (fMRI) to investigate the neural correlates during the anticipation of public and evaluated speaking vs a control condition in 17 SAD patients and 17 healthy control subjects. FMRI results show increased activation of the insula and decreased activation of the ventral striatum in SAD patients, compared to control subjects during anticipation of a speech vs the control condition. In addition, an activation of the amygdala in SAD patients during the first half of the anticipation phase in the speech condition was observed. Finally, the amount of anticipatory anxiety of SAD patients was negatively correlated to the activation of the ventral striatum. This suggests an association between incentive function, motivation and anticipatory anxiety when SAD patients expect a performance situation.
在预期与表现相关的情境时出现过度的预期焦虑是社交焦虑障碍（SAD）精神病理学的一个重要特征。在对照研究中尚未对SAD中预期焦虑的神经基础进行研究。当前研究使用功能磁共振成像（fMRI）来调查17名SAD患者和17名健康对照者在预期公开演讲和评估性演讲与对照条件下的神经关联。fMRI结果显示，与对照者相比，SAD患者在预期演讲与对照条件时，脑岛激活增加，腹侧纹状体激活减少。此外，在演讲条件下的预期阶段前半段观察到SAD患者杏仁核激活。最后，SAD患者的预期焦虑量与腹侧纹状体的激活呈负相关。这表明当SAD患者预期表现情境时，激励功能、动机与预期焦虑之间存在关联。
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