The Institute of Scientific and Industrial Research (ISIR), Osaka University, Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan.
Chem Commun (Camb). 2013 Sep 28;49(75):8392-4. doi: 10.1039/c3cc44549f.
The P-chirogenic organocatalysts were found to promote the enantioselective aza-Morita-Baylis-Hillman reaction of ketimines derived from acyclic α-keto esters. In the P-chirogenic organocatalyzed aza-MBH reactions, α,α-disubstituted α-amino acid derivatives were obtained in high yields with high enantioselectivities (up to 97% ee).
手性有机催化剂被发现可以促进由无环α-酮酯衍生的酮亚胺的对映选择性aza-Morita-Baylis-Hillman 反应。在手性有机催化的aza-MBH 反应中，α,α-二取代的α-氨基酸衍生物以高产率和高对映选择性（高达 97%ee）获得。
