Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi-221005, India.
Inorganic and Physical Chemistry Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500007, India.
Beilstein J Org Chem. 2014 Dec 12;10:2975-80. doi: 10.3762/bjoc.10.315. eCollection 2014.
The Morita-Baylis-Hillman reaction of acrylamide, as an activated alkene, has seen little development due to its low reactivity. We have developed the reaction using isatin derivatives with acrylamide, DABCO as a promoter and phenol as an additive in acetonitrile. The corresponding aza version with acrylate and acrylonitrile has also been developed resulting in high product yields.
由于丙烯酰胺反应活性低，作为一种活化的烯烃，Morita-Baylis-Hillman 反应的发展较少。我们使用色胺衍生物与丙烯酰胺、DABCO 作为促进剂和苯酚作为添加剂在乙腈中进行了反应。还开发了相应的带有丙烯酸酯和丙烯腈的氮杂版本，得到了高产率的产物。
