Department of Microbial and Biochemical Pharmacy, School of Pharmaceutical Sciences, Sun Yat-sen University, No. 132 Waihuandong Road, University Town, Guangzhou 510006, PR China; State Key Laboratory in Marine Pollution-Croucher Institute for Environmental Sciences, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
J Hazard Mater. 2013 Oct 15;261:253-9. doi: 10.1016/j.jhazmat.2013.07.033. Epub 2013 Jul 24.
There was limited information about bioaccumulation of polybrominated diphenyl ethers (PBDEs) in humans of the general population of Hong Kong. Therefore, the present study was conducted to determine concentrations and congener profiles of PBDEs in blood plasma from Hong Kong, evaluate their sources and correlations with other organobrominated compounds, and investigate exposure routes from fish and dust. Concentrations of ∑PBDE22 ranged from 0.56 to 92 ng g(-1), lipid weight (lw), with a median of 5.4 ng g(-1). BDE-47 was the dominant congener, accounting for 26% of ∑PBDE22. Concentrations of PBDE congeners in market fish were significantly (r(2)=0.89, p<0.001) correlated with plasma. Positive but no significant correlations were observed, between concentrations of PBDE congeners in indoor dust from workplaces (r(2)=0.46, p=0.081) and homes (r(2)=0.49, p=0.10), with concentrations of PBDE in human blood plasma. The results indicated that dietary exposure, particularly consumption of fish, is a major pathway through which people in Hong Kong are exposed to PBDEs. Furthermore, our data revealed a spatial distribution and terrestrial source of BDE-28 for local people. Results of the present study, which was the first systematic study to investigate concentrations of PBDEs in blood of Hong Kong people, provides useful information to which future measurements can be compared.
香港普通人群体中多溴二苯醚（PBDEs）的生物累积信息有限。因此，本研究旨在确定香港人血浆中 PBDEs 的浓度和同系物分布，评估其来源以及与其他有机溴化合物的相关性，并研究鱼类和灰尘暴露途径。∑PBDE22 的浓度范围为 0.56 至 92ng/g（以脂质重量计），中位数为 5.4ng/g。BDE-47 是主要的同系物，占∑PBDE22 的 26%。市场鱼类中的 PBDE 同系物浓度与血浆呈显著（r(2)=0.89，p<0.001）相关。工作场所（r(2)=0.46，p=0.081）和家庭（r(2)=0.49，p=0.10）室内灰尘中 PBDE 同系物的浓度与人体血浆中 PBDE 浓度之间存在正相关，但无统计学意义。结果表明，饮食暴露，特别是鱼类的摄入，是香港人接触 PBDEs 的主要途径。此外，我们的数据还揭示了 BDE-28 在当地人群中的空间分布和陆地来源。本研究是首次对香港人血液中 PBDEs 浓度进行的系统研究，为今后的测量提供了有价值的信息。
